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In intestinal fluid samples from 39 human immunodeficiency virus type 1 (HIV-1)-infected patients, IgA and IgG levels were equivalent, whereas in 10 controls, IgA levels were significantly higher than those of IgG (P < .05). Intestinal IgA in patients contained predominantly monomeric IgA1, whereas IgA1 and IgA2 subclass levels in controls were nearly equivalent and primarily polymeric. The predominance of IgG and monomeric IgA1 in mucosal fluid samples from HIV-1-infected patients suggests exudation of serum immunoglobulins into the intestine. The decreased proportion of mucosal plasma cells producing IgA and IgA2 in the HIV-1-infected patients (P < .01) may also contribute to the abnormal intestinal immunoglobulin levels. Intestinal IgG reacted with most HIV-1 antigens, whereas specific IgA was present in only 10 of 17 patients and reacted with only envelope (gp120 and gp160) and, less often, core (p17 and p24) antigens. Aberrant mucosal antibody responses and decreased integrity of the mucosal barrier may contribute to the intestinal dysfunction and infections that characterize HIV-1 infection.
E N Janoff, and
S Jackson, and
S M Wahl, and
K Thomas, and
J H Peterman, and
P D Smith
June 1993,
Digestive diseases and sciences,
E N Janoff, and
S Jackson, and
S M Wahl, and
K Thomas, and
J H Peterman, and
P D Smith
May 1999,
The Journal of infectious diseases,
E N Janoff, and
S Jackson, and
S M Wahl, and
K Thomas, and
J H Peterman, and
P D Smith
January 2016,
Voprosy virusologii,
E N Janoff, and
S Jackson, and
S M Wahl, and
K Thomas, and
J H Peterman, and
P D Smith
May 1999,
The Journal of infectious diseases,
E N Janoff, and
S Jackson, and
S M Wahl, and
K Thomas, and
J H Peterman, and
P D Smith
June 2005,
Current HIV/AIDS reports,
E N Janoff, and
S Jackson, and
S M Wahl, and
K Thomas, and
J H Peterman, and
P D Smith
July 1998,
The New England journal of medicine,
E N Janoff, and
S Jackson, and
S M Wahl, and
K Thomas, and
J H Peterman, and
P D Smith
August 2015,
Journal of virology,
E N Janoff, and
S Jackson, and
S M Wahl, and
K Thomas, and
J H Peterman, and
P D Smith
January 1995,
The Journal of infectious diseases,
E N Janoff, and
S Jackson, and
S M Wahl, and
K Thomas, and
J H Peterman, and
P D Smith
May 1999,
The Journal of infectious diseases,
E N Janoff, and
S Jackson, and
S M Wahl, and
K Thomas, and
J H Peterman, and
P D Smith
January 1995,
Annales de dermatologie et de venereologie,
