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Ten patients with active acromegaly were studied. In 9 plasma GH levels failed to suppress after glucose (OGTT), in 8 an increase in serum GH occurred after thyrotropin releasing hormone (TRH). After L-Dopa, 4 patients showed no change in serum GH, 3 exhibited a decrease and in 3 an increase in serum hGH occurred. With a combined insulin (ITT) and arginine (ATT) test, 2 patients exhibited an increase in hGH, and in 6 no change occurred. Fasting serum GH concentration was less than 11 ng/ml in 5 patients. Basal prolactin (hPRL) levels were normal in all patients including two with galactorrhea. L-Dopa suppressed and TRH stimulated hPRL secretion in all, but the responses which were seen were subnormal. Hydrocortisone infusion in two acromegalics did not affect the prolactin induced increase after TRH but blunted the GH increase after TRH.
G Tolis, and
L Kovacs, and
H Friesen, and
J B Martin
August 1994,
The Journal of clinical endocrinology and metabolism,
G Tolis, and
L Kovacs, and
H Friesen, and
J B Martin
August 1986,
The Journal of clinical endocrinology and metabolism,
G Tolis, and
L Kovacs, and
H Friesen, and
J B Martin
November 1986,
The Journal of clinical endocrinology and metabolism,
G Tolis, and
L Kovacs, and
H Friesen, and
J B Martin
January 1973,
The Mount Sinai journal of medicine, New York,
G Tolis, and
L Kovacs, and
H Friesen, and
J B Martin
April 1980,
Revista brasileira de pesquisas medicas e biologicas,
G Tolis, and
L Kovacs, and
H Friesen, and
J B Martin
January 1993,
Hormone research,
G Tolis, and
L Kovacs, and
H Friesen, and
J B Martin
October 1988,
Journal of endocrinological investigation,
G Tolis, and
L Kovacs, and
H Friesen, and
J B Martin
April 1976,
Klinische Wochenschrift,
G Tolis, and
L Kovacs, and
H Friesen, and
J B Martin
February 1989,
The Journal of clinical endocrinology and metabolism,
G Tolis, and
L Kovacs, and
H Friesen, and
J B Martin
February 1976,
Lancet (London, England),
