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Interleukin 10 (IL-10) is produced by TH2 lymphocytes and regulates both lymphoid and myeloid cells. In the present study we demonstrate that IL-10 is expressed and produced spontaneously in the peripheral blood mononuclear cells (PBMCs) of all HIV-1 infected individuals tested, 3 of 19 cases of HIV-negative lymphoma and none of five healthy controls. IL-10 mRNA was detectable in both monocytes/macrophages and T lymphocytes isolated from PBMCs of HIV infected patients. We have also shown that infection of promonocytic (U937) and T (H9) cell lines with HIV stimulates IL-10 secretion. Furthermore, a T cell line (H9) stably transfected with a HIV tat expression-vector secreted higher levels of IL-10. We have also demonstrated that rhIL-10 inhibited HIV-1 replication in infected monocytes and PBMCs in a dose dependent manner. IL-10 may thus participate in long latency between HIV-1 infection and development of AIDS.
R Masood, and
Y Lunardi-Iskandar, and
T Moudgil, and
Y Zhang, and
R E Law, and
C L Huang, and
R K Puri, and
A M Levine, and
P S Gill
June 1996,
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R Masood, and
Y Lunardi-Iskandar, and
T Moudgil, and
Y Zhang, and
R E Law, and
C L Huang, and
R K Puri, and
A M Levine, and
P S Gill
December 2014,
Virology journal,
R Masood, and
Y Lunardi-Iskandar, and
T Moudgil, and
Y Zhang, and
R E Law, and
C L Huang, and
R K Puri, and
A M Levine, and
P S Gill
November 2018,
PLoS pathogens,
R Masood, and
Y Lunardi-Iskandar, and
T Moudgil, and
Y Zhang, and
R E Law, and
C L Huang, and
R K Puri, and
A M Levine, and
P S Gill
June 2021,
Journal of virology,
R Masood, and
Y Lunardi-Iskandar, and
T Moudgil, and
Y Zhang, and
R E Law, and
C L Huang, and
R K Puri, and
A M Levine, and
P S Gill
December 1994,
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R Masood, and
Y Lunardi-Iskandar, and
T Moudgil, and
Y Zhang, and
R E Law, and
C L Huang, and
R K Puri, and
A M Levine, and
P S Gill
October 2001,
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R Masood, and
Y Lunardi-Iskandar, and
T Moudgil, and
Y Zhang, and
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A M Levine, and
P S Gill
November 2004,
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R Masood, and
Y Lunardi-Iskandar, and
T Moudgil, and
Y Zhang, and
R E Law, and
C L Huang, and
R K Puri, and
A M Levine, and
P S Gill
January 2010,
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R Masood, and
Y Lunardi-Iskandar, and
T Moudgil, and
Y Zhang, and
R E Law, and
C L Huang, and
R K Puri, and
A M Levine, and
P S Gill
January 1994,
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R Masood, and
Y Lunardi-Iskandar, and
T Moudgil, and
Y Zhang, and
R E Law, and
C L Huang, and
R K Puri, and
A M Levine, and
P S Gill
June 2016,
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