BIOMAT Database Logo BIOMAT Database Logo

The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice. 1994

H Fujiwara, and H Kikutani, and S Suematsu, and T Naka, and K Yoshida, and K Yoshida, and T Tanaka, and M Suemura, and N Matsumoto, and S Kojima
Research Institute, Osaka Medical Center for Maternal and Child Health, Japan.

The CD23 antigen, a low-affinity receptor for IgE (Fc epsilon RII), is a type II membrane-bound glycoprotein expressed on various cells, particularly mature B cells. A number of functions have been ascribed to CD23, including specific regulation of IgE production, IgE-mediated cytotoxicity and release of mediators, IgE-dependent antigen focusing, promotion of B-cell growth, prevention of germinal center B cells from apoptosis, proliferation of myeloid precursors, and maturation of early thymocytes. It is not clear whether these activities represent in vivo functions. To explore in vivo functions of CD23, we have produced CD23-deficient mice. These mice displayed normal lymphocyte differentiation and could mount normal antibody responses, including IgE responses upon immunization with T-dependent antigens and infection with Nippostrongyrus brasiliensis. Germinal center formation after immunization and in vitro proliferative response of B cells were not affected in mutant mice. However, antigen-specific IgE-mediated enhancement of antibody responses was severely impaired.

UI MeSH Term Description Entries
D007073 Immunoglobulin E An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE). IgE
D008856 Microscopy, Fluorescence Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye. Fluorescence Microscopy,Immunofluorescence Microscopy,Microscopy, Immunofluorescence,Fluorescence Microscopies,Immunofluorescence Microscopies,Microscopies, Fluorescence,Microscopies, Immunofluorescence
D010641 Phenotype The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment. Phenotypes
D002454 Cell Differentiation Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs. Differentiation, Cell,Cell Differentiations,Differentiations, Cell
D002455 Cell Division The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION. M Phase,Cell Division Phase,Cell Divisions,Division Phase, Cell,Division, Cell,Divisions, Cell,M Phases,Phase, Cell Division,Phase, M,Phases, M
D004797 Enzyme-Linked Immunosorbent Assay An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed. ELISA,Assay, Enzyme-Linked Immunosorbent,Assays, Enzyme-Linked Immunosorbent,Enzyme Linked Immunosorbent Assay,Enzyme-Linked Immunosorbent Assays,Immunosorbent Assay, Enzyme-Linked,Immunosorbent Assays, Enzyme-Linked
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000917 Antibody Formation The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS. Antibody Production,Antibody Response,Antibody Responses,Formation, Antibody,Production, Antibody,Response, Antibody,Responses, Antibody
D001402 B-Lymphocytes Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. B-Cells, Lymphocyte,B-Lymphocyte,Bursa-Dependent Lymphocytes,B Cells, Lymphocyte,B Lymphocyte,B Lymphocytes,B-Cell, Lymphocyte,Bursa Dependent Lymphocytes,Bursa-Dependent Lymphocyte,Lymphocyte B-Cell,Lymphocyte B-Cells,Lymphocyte, Bursa-Dependent,Lymphocytes, Bursa-Dependent
D013154 Spleen An encapsulated lymphatic organ through which venous blood filters.

Related Publications

H Fujiwara, and H Kikutani, and S Suematsu, and T Naka, and K Yoshida, and K Yoshida, and T Tanaka, and M Suemura, and N Matsumoto, and S Kojima
IgE enhances specific antibody and T-cell responses in mice overexpressing CD23.
January 2007, Scandinavian journal of immunology,
H Fujiwara, and H Kikutani, and S Suematsu, and T Naka, and K Yoshida, and K Yoshida, and T Tanaka, and M Suemura, and N Matsumoto, and S Kojima
Restoration of the antibody response to IgE/antigen complexes in CD23-deficient mice by CD23+ spleen or bone marrow cells.
April 2000, Journal of immunology (Baltimore, Md. : 1950),
H Fujiwara, and H Kikutani, and S Suematsu, and T Naka, and K Yoshida, and K Yoshida, and T Tanaka, and M Suemura, and N Matsumoto, and S Kojima
CD23/IgE-mediated regulation of the specific antibody response in vivo.
May 1994, Journal of immunology (Baltimore, Md. : 1950),
H Fujiwara, and H Kikutani, and S Suematsu, and T Naka, and K Yoshida, and K Yoshida, and T Tanaka, and M Suemura, and N Matsumoto, and S Kojima
Regulation of IgE synthesis. Lessons from the study of IgE transgenic and CD23-deficient mice.
December 1995, Immunological reviews,
H Fujiwara, and H Kikutani, and S Suematsu, and T Naka, and K Yoshida, and K Yoshida, and T Tanaka, and M Suemura, and N Matsumoto, and S Kojima
Relationships between IgE antibody production and other immune responses I. Ontogenic development of IgE antibody-producing capacity in mice.
January 1977, International archives of allergy and applied immunology,
H Fujiwara, and H Kikutani, and S Suematsu, and T Naka, and K Yoshida, and K Yoshida, and T Tanaka, and M Suemura, and N Matsumoto, and S Kojima
IgE enhances antibody and T cell responses in vivo via CD23+ B cells.
August 2005, Journal of immunology (Baltimore, Md. : 1950),
H Fujiwara, and H Kikutani, and S Suematsu, and T Naka, and K Yoshida, and K Yoshida, and T Tanaka, and M Suemura, and N Matsumoto, and S Kojima
IgE-mediated enhancement of antibody responses: the beneficial function of IgE?
July 2002, Allergy,
H Fujiwara, and H Kikutani, and S Suematsu, and T Naka, and K Yoshida, and K Yoshida, and T Tanaka, and M Suemura, and N Matsumoto, and S Kojima
IgE-Mediated Immune Response and Antibody-Mediated Rejection.
October 2020, Clinical journal of the American Society of Nephrology : CJASN,
H Fujiwara, and H Kikutani, and S Suematsu, and T Naka, and K Yoshida, and K Yoshida, and T Tanaka, and M Suemura, and N Matsumoto, and S Kojima
IgE-mediated suppression of primary antibody responses in vivo.
April 2001, Scandinavian journal of immunology,
H Fujiwara, and H Kikutani, and S Suematsu, and T Naka, and K Yoshida, and K Yoshida, and T Tanaka, and M Suemura, and N Matsumoto, and S Kojima
IgE regulation in CD23 knockout and transgenic mice.
November 1999, Allergy,
Copied contents to your clipboard!