-transparent.png){kind=logo}
The purpose of this study was to compare the ability of intravenously administered methamphetamine and cocaine to facilitate dopaminergic transmission, based on the ability of these drugs to induce rotational behavior in rats with unilateral 6-hydroxydopamine lesions of the substantia nigra. The doses of methamphetamine and cocaine ranged from 0.25 mg/kg to 4 mg/kg which was equivalent to 50% of the minimum dose which caused convulsion. Methamphetamine induced more marked ipsilateral rotational behavior than did cocaine. The present results suggest that methamphetamine produces longer duration of the facilitation of dopaminergic transmission both in the nucleus accumbens and in the striatum than does cocaine.
H Miyata, and
N Hironaka, and
K Ando, and
T Yanagita
October 1979,
The Journal of pharmacology and experimental therapeutics,
H Miyata, and
N Hironaka, and
K Ando, and
T Yanagita
December 1970,
Brain research,
H Miyata, and
N Hironaka, and
K Ando, and
T Yanagita
June 1992,
Pharmacology, biochemistry, and behavior,
H Miyata, and
N Hironaka, and
K Ando, and
T Yanagita
February 1986,
Brain research,
H Miyata, and
N Hironaka, and
K Ando, and
T Yanagita
December 1975,
Brain research,
H Miyata, and
N Hironaka, and
K Ando, and
T Yanagita
July 1977,
European journal of pharmacology,
H Miyata, and
N Hironaka, and
K Ando, and
T Yanagita
October 1993,
Brain research,
H Miyata, and
N Hironaka, and
K Ando, and
T Yanagita
December 2006,
Acta medica Okayama,
H Miyata, and
N Hironaka, and
K Ando, and
T Yanagita
December 1982,
Neurology,
H Miyata, and
N Hironaka, and
K Ando, and
T Yanagita
July 1984,
Medical & biological engineering & computing,
