-transparent.png){kind=logo}
The aim of the study was to investigate blood pressure responses and changes in heart rate after bolus administration of endothelin-3 [ET-3] in conscious, freely moving SHR and WKY rats and DOCA-salt hypertensive and normotensive Wistar rats. The effect of ET-3 on blood pressure and heart rats was investigated for four doses equal to 250 ng, 500 ng, 1000 ng and 2000 ng of ET-3. Our study shows that in experimental models of hypertension changes in blood pressure were predominantly characterized by the pronounced hypotensive phase with no significant raises in blood pressure. In normotensive animals cardiovascular responses to ET-3 were biphasic, with initial depressor phase followed by long-lasting, significant pressor effect.
A Januszewicz, and
S Loń, and
M Lapiński, and
A Styś
June 1993,
Blood pressure,
A Januszewicz, and
S Loń, and
M Lapiński, and
A Styś
January 1993,
Life sciences,
A Januszewicz, and
S Loń, and
M Lapiński, and
A Styś
January 1990,
Clinical and experimental hypertension. Part A, Theory and practice,
A Januszewicz, and
S Loń, and
M Lapiński, and
A Styś
March 1990,
Biochemical and biophysical research communications,
A Januszewicz, and
S Loń, and
M Lapiński, and
A Styś
August 1995,
British journal of pharmacology,
A Januszewicz, and
S Loń, and
M Lapiński, and
A Styś
January 1989,
Journal of cardiovascular pharmacology,
A Januszewicz, and
S Loń, and
M Lapiński, and
A Styś
January 2015,
International journal of clinical and experimental medicine,
A Januszewicz, and
S Loń, and
M Lapiński, and
A Styś
January 2004,
Methods and findings in experimental and clinical pharmacology,
A Januszewicz, and
S Loń, and
M Lapiński, and
A Styś
August 1984,
Acta medica Okayama,
A Januszewicz, and
S Loń, and
M Lapiński, and
A Styś
October 1979,
Jikken dobutsu. Experimental animals,
