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A method for the determination of delta-aminolevulinic acid in plasma of lead-exposed workers by high-performance liquid chromatography with fluorescence detection of a fluorescent delta-aminolevulinic acid derivative (2-methylidineamino-3,5-diacetyl-4,6-dimethylpropionic acid) was established. The detection limit of delta-aminolevulinic acid in plasma was 0.01 microgram/ml at a signal-to-noise ratio of 5:1. A linear correlation was obtained between the amounts of delta-aminolevulinic acid injected from 0.01 to 0.5 microgram/ml (r = 0.999). The recovery of 0.05 and 0.1 microgram/ml of delta-aminolevulinic acid added to plasma with various concentrations of delta-aminolevulinic acid in plasma ranged from 80.0 to 100.8%. This method, combined with the use of an automatic sampler, should facilitate the routine measurement of delta-aminolevulinic acid in plasma.
K Miyajima, and
M Hirata, and
T Yoshida, and
H Kosaka, and
A Okayama
June 1991,
Journal of chromatography,
K Miyajima, and
M Hirata, and
T Yoshida, and
H Kosaka, and
A Okayama
July 1992,
Chemical & pharmaceutical bulletin,
K Miyajima, and
M Hirata, and
T Yoshida, and
H Kosaka, and
A Okayama
January 1994,
Industrial health,
K Miyajima, and
M Hirata, and
T Yoshida, and
H Kosaka, and
A Okayama
April 1988,
Journal of chromatography,
K Miyajima, and
M Hirata, and
T Yoshida, and
H Kosaka, and
A Okayama
February 1977,
Biochemical medicine,
K Miyajima, and
M Hirata, and
T Yoshida, and
H Kosaka, and
A Okayama
February 1986,
Journal of chromatography,
K Miyajima, and
M Hirata, and
T Yoshida, and
H Kosaka, and
A Okayama
May 1987,
Journal of chromatography,
K Miyajima, and
M Hirata, and
T Yoshida, and
H Kosaka, and
A Okayama
October 1976,
British journal of clinical pharmacology,
K Miyajima, and
M Hirata, and
T Yoshida, and
H Kosaka, and
A Okayama
January 1986,
Industrial health,
K Miyajima, and
M Hirata, and
T Yoshida, and
H Kosaka, and
A Okayama
August 1985,
Analytical biochemistry,
