The findings of serum diagnosis (urea nitrogen, creatinine, uric acid, calcium, phosphorus) in 247 patients with oxalate stone were divided according to sex, and the excretion of uric acid, calcium and phosphorus was estimated. Compared with the control group, the levels of serum uric acid and serum calcium were statistically significantly raised, the mean level not exceeding the normal range. The serum uric acid level was 25% above the normal range in men and 20% above in women, and in the upper range of normal in one third of each, men and women. The excretion of uric acid in women exceeds the normal level in 32% of cases and in 40% of the men, sometimes considerably. The connection between pathological uric acid levels in the serum and urine and the development of oxalate stone, as well as the therapeutic consequences are discussed.