-transparent.png){kind=logo}
Recently, a genetic control of serum ACE (SACE) levels has been suggested by the identification of an insertion/deletion (I/D) polymorphism of the ACE gene by Rigat et al. We have also confirmed significant association between ACE gene polymorphism and SACE activities both in controls and sarcoidosis and established the new reference intervals of SACE activities for each genotype. The new reference intervals improved discrimination between normal and abnormal SACE activities. The frequencies of two alleles (I/D) in Japanese were quite different from those in whites and the insertion allele was dominant in Japanese. This genetic variation may affect the pathogenesis and prognosis of various diseases such as sarcoidosis and ischemic heart diseases.
K Furuya, and
E Yamaguchi, and
Y Kawakami
January 1978,
Duodecim; laaketieteellinen aikakauskirja,
K Furuya, and
E Yamaguchi, and
Y Kawakami
July 1997,
American journal of respiratory and critical care medicine,
K Furuya, and
E Yamaguchi, and
Y Kawakami
May 1978,
Nihon rinsho. Japanese journal of clinical medicine,
K Furuya, and
E Yamaguchi, and
Y Kawakami
May 1998,
Biochemical Society transactions,
K Furuya, and
E Yamaguchi, and
Y Kawakami
September 1975,
The American journal of medicine,
K Furuya, and
E Yamaguchi, and
Y Kawakami
April 1981,
Irish medical journal,
K Furuya, and
E Yamaguchi, and
Y Kawakami
December 1989,
Clinics in laboratory medicine,
K Furuya, and
E Yamaguchi, and
Y Kawakami
January 1976,
Annals of the New York Academy of Sciences,
K Furuya, and
E Yamaguchi, and
Y Kawakami
April 2005,
Pathologie-biologie,
K Furuya, and
E Yamaguchi, and
Y Kawakami
October 1980,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
