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Sarcoidosis is a multisystem granulomatous disorder of unknown etiology presenting with bilateral hilar lymphadenopathy, pulmonary, skin, and eye lesion. Sarcoidosis involving skeletal muscle is not uncommon because non caseating granuloma have been demonstrated in as much as 50 to 80% of sarcoidosis cases. Symptomatic muscle involvement, however, is rare. Chronic and acute myopathy and palpable nodular lesions due to sarcoidosis involving skeletal muscle have been reported. Chronic myopathy is progressive muscle disease with muscle weakness and wasting. Because this syndrome is rare, its natural history and responsiveness to corticosteroid have not been defined well. We review the medical literature of previously reported cases of muscular sarcoidosis.
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