Charge distribution of high density lipoproteins (HDL) from the human aorta intima has been studied using the method of isoelectric focusing in the polyacrylamide gel. Four groups of aortal HDL (A-HDL) were identified by focusing in the pH range 4.6-6.0: 1) the prevailing group (pH 4.7-4.9); 2) the intermediate, the most heterogeneous group (pI 5.0-5.9), including to 15-17 subfractions (these two groups are also present in the plasma); 3) the cathodic group (pI 6.0) practically absent in the plasma and one of the main groups among A-HDL (22% of all A-HDL), certain subfractions of this group have pI about 6.9; 4) the anodic group (pI 3.75), a minor group (5% of all A-HDL), also absent in the plasma. No differences are found between charge distribution of HDL from the normal aorta intima and atherosclerosis-affected intima. The data obtained confirm that plasmic HDL penetrating to the arterial intima are subjected to considerable changes in it.