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Blood serum cytotoxic activity of women with acute inflammatory diseases of the internal genitals was studied over the course of combined therapy, including immunomodulators, making use of target cells sensitive to the tumor necrosis factor (TNF). The levels of TNF activities varied within a wide range at the moment of the patients' admittance to hospital. TNF levels were high in the majority of patients or were increasing over the course of treatment. A low cytotoxic activity or its stable level over the course of treatment may be explained by a reduction of the immunocompetent cells functional activity.
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