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Spontaneous Clostridium septicum myonecrosis is an uncommon disorder that has been described in association with malignancy, immunosuppression and neutropaenia. Typical clostridial myonecrosis develops without a visible portal of entry and mortality is high. The pathogenesis is not completely understood but the clostridia may gain access to the circulation via areas of ileo-caecal ulceration secondary to enterocolitis, antibiotics or neoplasms. A 5 year old boy with congenital neutropaenia presented with spontaneous Clostridium septicum myonecrosis in the thigh. Limb salvage was achieved using antibiotics, hyberbaric oxygenation and selective debridement. The portal of entry may have been the gastrointestinal tract as colonic ulceration may occur in neutropaenia, and pre-morbid clindamycin administration may have encouraged overgrowth of colonic clostridia.
G Keogh, and
I Unsworth, and
M Vowels, and
I B Kern
November 1987,
Indiana medicine : the journal of the Indiana State Medical Association,
G Keogh, and
I Unsworth, and
M Vowels, and
I B Kern
December 2004,
Pediatrics,
G Keogh, and
I Unsworth, and
M Vowels, and
I B Kern
October 2009,
Journal of plastic, reconstructive & aesthetic surgery : JPRAS,
G Keogh, and
I Unsworth, and
M Vowels, and
I B Kern
November 1993,
Australasian radiology,
G Keogh, and
I Unsworth, and
M Vowels, and
I B Kern
May 2022,
International journal of hematology,
G Keogh, and
I Unsworth, and
M Vowels, and
I B Kern
May 1999,
Australasian radiology,
G Keogh, and
I Unsworth, and
M Vowels, and
I B Kern
November 1983,
Diseases of the colon and rectum,
G Keogh, and
I Unsworth, and
M Vowels, and
I B Kern
December 1988,
Connecticut medicine,
G Keogh, and
I Unsworth, and
M Vowels, and
I B Kern
October 2004,
The New England journal of medicine,
G Keogh, and
I Unsworth, and
M Vowels, and
I B Kern
June 2011,
The American surgeon,
