BIOMAT Database Logo BIOMAT Database Logo

Inhaled platelet-activating factor worsens gas exchange in mild asthma. 1994

M A Félez, and J Roca, and J A Barberà, and C Santos, and M Rotger, and K F Chung, and R Rodriguez-Roisin
Servei de Pneumologia i Al.lèrgia Respiratòria, Hospital Clinic, Laboratori de Biofísica i Bioenginyería, Facultat de Medicina, Universitat de Barcelona, Spain.

To investigate the potential effects of inhaled platelet-activating-factor (PAF) (12 micrograms) to perturb pulmonary gas exchange in bronchial asthma, six patients (mean +/- SE, 23 +/- 2 yr) with intermittent asthma (FEV1, 90% predicted) were studied before and 5, 15, and 45 min after challenge. Circulating white blood cells, respiratory system resistance (Rrs), systemic and pulmonary hemodynamics, and respiratory and inert pulmonary gas exchange were measured. Five minutes after PAF leukocytes fell, Rrs increased (by 27%). PaO2 decreased (by 15 mm Hg), and AaPO2 increased (twofold) (p < 0.05 each). Ventilation-perfusion (Va/Q) distributions worsened in a pattern similar to that commonly observed in patients with moderate to severe asthma. Dispersions of pulmonary blood flow (log SD Q) and of alveolar ventilation (log SD V), and an overall index of Va/Q heterogeneity (DISP R-E*) increased significantly (123% for DISP R-E*; p < 0.05, each). Gas exchange indices and Rrs were still minimally abnormal at 15 min but returned towards baseline at 45 min. Ventilatory and hemodynamic variables remained unaltered throughout the study. These results suggest that endogenous PAF may be implicated in the arterial blood gas abnormalities shown during exacerbations of bronchial asthma.

UI MeSH Term Description Entries
D007958 Leukocyte Count The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells. Blood Cell Count, White,Differential Leukocyte Count,Leukocyte Count, Differential,Leukocyte Number,White Blood Cell Count,Count, Differential Leukocyte,Count, Leukocyte,Counts, Differential Leukocyte,Counts, Leukocyte,Differential Leukocyte Counts,Leukocyte Counts,Leukocyte Counts, Differential,Leukocyte Numbers,Number, Leukocyte,Numbers, Leukocyte
D008297 Male Males
D010972 Platelet Activating Factor A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION. AGEPC,Acetyl Glyceryl Ether Phosphorylcholine,PAF-Acether,Phosphorylcholine, Acetyl Glyceryl Ether,1-Alkyl-2-acetyl-sn-glycerophosphocholine,Platelet Aggregating Factor,Platelet Aggregation Enhancing Factor,Platelet-Activating Substance,Thrombocyte Aggregating Activity,1 Alkyl 2 acetyl sn glycerophosphocholine,Aggregating Factor, Platelet,Factor, Platelet Activating,PAF Acether,Platelet Activating Substance
D011659 Pulmonary Gas Exchange The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER. Exchange, Pulmonary Gas,Gas Exchange, Pulmonary
D005260 Female Females
D006439 Hemodynamics The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM. Hemodynamic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000280 Administration, Inhalation The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract. Drug Administration, Inhalation,Drug Administration, Respiratory,Drug Aerosol Therapy,Inhalation Drug Administration,Inhalation of Drugs,Respiratory Drug Administration,Aerosol Drug Therapy,Aerosol Therapy, Drug,Drug Therapy, Aerosol,Inhalation Administration,Administration, Inhalation Drug,Administration, Respiratory Drug,Therapy, Aerosol Drug,Therapy, Drug Aerosol
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

M A Félez, and J Roca, and J A Barberà, and C Santos, and M Rotger, and K F Chung, and R Rodriguez-Roisin
Fluticasone propionate attenuates platelet-activating factor-induced gas exchange defects in mild asthma.
May 2002, The European respiratory journal,
M A Félez, and J Roca, and J A Barberà, and C Santos, and M Rotger, and K F Chung, and R Rodriguez-Roisin
Effects of inhaled furosemide on platelet-activating factor challenge in mild asthma.
September 1999, The European respiratory journal,
M A Félez, and J Roca, and J A Barberà, and C Santos, and M Rotger, and K F Chung, and R Rodriguez-Roisin
Effect of a platelet-activating factor (PAF) antagonist, SR 27417A, on PAF-induced gas exchange abnormalities in mild asthma.
April 1998, The European respiratory journal,
M A Félez, and J Roca, and J A Barberà, and C Santos, and M Rotger, and K F Chung, and R Rodriguez-Roisin
Platelet activating factor and asthma.
October 1986, Agents and actions,
M A Félez, and J Roca, and J A Barberà, and C Santos, and M Rotger, and K F Chung, and R Rodriguez-Roisin
Platelet activating factor and asthma.
January 1991, Annals of the New York Academy of Sciences,
M A Félez, and J Roca, and J A Barberà, and C Santos, and M Rotger, and K F Chung, and R Rodriguez-Roisin
Platelet-activating factor and asthma.
January 1988, The Journal of allergy and clinical immunology,
M A Félez, and J Roca, and J A Barberà, and C Santos, and M Rotger, and K F Chung, and R Rodriguez-Roisin
[Platelet activating factor and platelet activating factor antagonists. New methods in asthma therapy?].
June 1989, Medizinische Monatsschrift fur Pharmazeuten,
M A Félez, and J Roca, and J A Barberà, and C Santos, and M Rotger, and K F Chung, and R Rodriguez-Roisin
Platelet activating factor, ketotifen and asthma.
August 1986, The New Zealand medical journal,
M A Félez, and J Roca, and J A Barberà, and C Santos, and M Rotger, and K F Chung, and R Rodriguez-Roisin
Platelet activating factor, ketotifen and asthma.
October 1986, The New Zealand medical journal,
M A Félez, and J Roca, and J A Barberà, and C Santos, and M Rotger, and K F Chung, and R Rodriguez-Roisin
[Platelet-activating factor antagonists and asthma].
April 1992, Sheng li ke xue jin zhan [Progress in physiology],
Copied contents to your clipboard!