BIOMAT Database Logo BIOMAT Database Logo

Plasma levels of lipoprotein(a) are elevated in patients with the antiphospholipid antibody syndrome. 1994

M Yamazaki, and H Asakura, and H Jokaji, and M Saito, and C Uotani, and I Kumabashiri, and E Morishita, and K Aoshima, and T Ikeda, and T Matsuda
Third Department of Internal Medicine, Kanazawa University School of Medicine, Japan.

The mechanisms underlying clinical abnormalities associated with the antiphospholipid antibody syndrome (APAS) have not been elucidated. We measured plasma levels of lipoprotein(a) [Lp(a)], the active form of plasminogen activator inhibitor (active PAI), thrombin-antithrombin III complex (TAT) and soluble thrombomodulin (TM), to investigate the relationship of these factors to thrombotic events in APAS. Mean plasma levels of Lp(a), TAT, active PAI and TM were all significantly higher in patients with aPL than in a control group of subjects. Plasma levels of Lp(a) and active PAI were significantly higher in patients with aPL and arterial thromboses than in patients with aPL but only venous thromboses. There was a significant correlation between plasma levels of Lp(a) and active PAI in patients with aPL. These findings suggest that patients with aPL are in hypercoagulable state. High levels of Lp(a) in plasma may impair the fibrinolytic system resulting in thromboses, especially in the arterial system.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010447 Peptide Hydrolases Hydrolases that specifically cleave the peptide bonds found in PROTEINS and PEPTIDES. Examples of sub-subclasses for this group include EXOPEPTIDASES and ENDOPEPTIDASES. Peptidase,Peptidases,Peptide Hydrolase,Protease,Proteases,Proteinase,Proteinases,Proteolytic Enzyme,Proteolytic Enzymes,Esteroproteases,Enzyme, Proteolytic,Hydrolase, Peptide
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D004198 Disease Susceptibility A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases. Diathesis,Susceptibility, Disease,Diatheses,Disease Susceptibilities,Susceptibilities, Disease
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000026 Abortion, Habitual Three or more consecutive spontaneous abortions. Abortion, Recurrent,Miscarriage, Recurrent,Recurrent Early Pregnancy Loss,Habitual Abortion,Habitual Abortions,Recurrent Abortion,Recurrent Abortions,Recurrent Miscarriage,Recurrent Miscarriages
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

M Yamazaki, and H Asakura, and H Jokaji, and M Saito, and C Uotani, and I Kumabashiri, and E Morishita, and K Aoshima, and T Ikeda, and T Matsuda
Elevated plasma lipoprotein(a) level and its association with impaired fibrinolysis in patients with antiphospholipid syndrome.
January 1998, The Journal of rheumatology,
M Yamazaki, and H Asakura, and H Jokaji, and M Saito, and C Uotani, and I Kumabashiri, and E Morishita, and K Aoshima, and T Ikeda, and T Matsuda
Elevated plasma lipoprotein(a) in patients with the nephrotic syndrome.
August 1993, Annals of internal medicine,
M Yamazaki, and H Asakura, and H Jokaji, and M Saito, and C Uotani, and I Kumabashiri, and E Morishita, and K Aoshima, and T Ikeda, and T Matsuda
Elevated anti-annexin V antibody levels in antiphospholipid syndrome and their involvement in antiphospholipid antibody specificities.
October 2000, American journal of clinical pathology,
M Yamazaki, and H Asakura, and H Jokaji, and M Saito, and C Uotani, and I Kumabashiri, and E Morishita, and K Aoshima, and T Ikeda, and T Matsuda
Elevated lipoprotein (a) levels are associated with the acute myocardial infarction in patients with normal low-density lipoprotein cholesterol levels.
April 2019, Bioscience reports,
M Yamazaki, and H Asakura, and H Jokaji, and M Saito, and C Uotani, and I Kumabashiri, and E Morishita, and K Aoshima, and T Ikeda, and T Matsuda
Elevated plasma lipoprotein(a) levels and hypoalbuminemia in peritoneal dialysis patients.
December 1995, The International journal of artificial organs,
M Yamazaki, and H Asakura, and H Jokaji, and M Saito, and C Uotani, and I Kumabashiri, and E Morishita, and K Aoshima, and T Ikeda, and T Matsuda
KL-6 levels are elevated in plasma from patients with acute respiratory distress syndrome.
January 2004, The European respiratory journal,
M Yamazaki, and H Asakura, and H Jokaji, and M Saito, and C Uotani, and I Kumabashiri, and E Morishita, and K Aoshima, and T Ikeda, and T Matsuda
Elevated plasma levels of endothelin in patients with sepsis syndrome.
April 1991, Circulatory shock,
M Yamazaki, and H Asakura, and H Jokaji, and M Saito, and C Uotani, and I Kumabashiri, and E Morishita, and K Aoshima, and T Ikeda, and T Matsuda
Lipoprotein-free amyloidogenic peptides in plasma are elevated in patients with sporadic Alzheimer's disease and Down's syndrome.
April 1999, Annals of neurology,
M Yamazaki, and H Asakura, and H Jokaji, and M Saito, and C Uotani, and I Kumabashiri, and E Morishita, and K Aoshima, and T Ikeda, and T Matsuda
Actual situation of lipoprotein apheresis in patients with elevated lipoprotein(a) levels.
December 2019, Atherosclerosis. Supplements,
M Yamazaki, and H Asakura, and H Jokaji, and M Saito, and C Uotani, and I Kumabashiri, and E Morishita, and K Aoshima, and T Ikeda, and T Matsuda
Elevated lipoprotein (a) levels in primary nephrotic syndrome.
December 1993, American journal of kidney diseases : the official journal of the National Kidney Foundation,
Copied contents to your clipboard!