-transparent.png){kind=logo}
Combination of TSH and Interleukin-6 (IL-6) can stimulate DNA synthesis in FRTL-5 cells. Phorbol 12-myristate 13-acetate (PMA) stimulates G0 to G1 transition but inhibits G1 to S transition in these cells. We studied the effect of IL-6 on DNA synthesis in TSH-pretreated FRTL-5 cells in the presence or absence of PMA. IL-6 induced DNA synthesis when it was added to TSH-pretreated cells. Further, PMA inhibited the DNA synthesis induced by IL-6. These data might suggest that in FRTL-5 cells IL-6 can show its mitogenic effect in G1 phase of their cell cycle progression.
Related Publications
S Nishiyama, and
T Takano, and
K Takada, and
H Tada, and
N Amino
February 1996,
Thyroid : official journal of the American Thyroid Association,
S Nishiyama, and
T Takano, and
K Takada, and
H Tada, and
N Amino
June 1997,
Journal of cellular physiology,
S Nishiyama, and
T Takano, and
K Takada, and
H Tada, and
N Amino
September 1994,
Annals of the New York Academy of Sciences,
S Nishiyama, and
T Takano, and
K Takada, and
H Tada, and
N Amino
January 1990,
Hormone and metabolic research. Supplement series,
S Nishiyama, and
T Takano, and
K Takada, and
H Tada, and
N Amino
December 1986,
Nihon Naibunpi Gakkai zasshi,
S Nishiyama, and
T Takano, and
K Takada, and
H Tada, and
N Amino
May 1986,
Endocrinology,
S Nishiyama, and
T Takano, and
K Takada, and
H Tada, and
N Amino
September 1996,
Oncology reports,
S Nishiyama, and
T Takano, and
K Takada, and
H Tada, and
N Amino
December 1992,
Biochemical and biophysical research communications,
S Nishiyama, and
T Takano, and
K Takada, and
H Tada, and
N Amino
August 2006,
Thyroid : official journal of the American Thyroid Association,
S Nishiyama, and
T Takano, and
K Takada, and
H Tada, and
N Amino
January 1999,
Life sciences,
