BIOMAT Database Logo BIOMAT Database Logo

Stability study of nitroglycerin sublingual tablets. 1975

D P Page, and N A Carson, and C A Buhr, and P E Flinn, and C E Wells, and M T Randall

Nitroglycerin sublingual tablets were studied over a 1-year period to determine tablet stability in terms of loss of strength, uniformity of tablets, and degradation of the drug itself. Tablets from six different firms were analyzed by a semiautomated procedure. The samples included two molded tablets and four compressed tablets, ranging in age at the time of initial assay from 40 days to over 1 year. The results indicated that there is a loss of strength of nitroglycerin tablets and that refrigeration slows down this loss. The study also indicated that these tablets were stable during the year of testing in terms of tablet uniformity and degradation of nitroglycerin.

UI MeSH Term Description Entries
D007202 Indicators and Reagents Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499) Indicator,Reagent,Reagents,Indicators,Reagents and Indicators
D007700 Kinetics The rate dynamics in chemical or physical systems.
D008722 Methods A series of steps taken in order to conduct research. Techniques,Methodological Studies,Methodological Study,Procedures,Studies, Methodological,Study, Methodological,Method,Procedure,Technique
D002855 Chromatography, Thin Layer Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Chromatography, Thin-Layer,Thin Layer Chromatography,Chromatographies, Thin Layer,Chromatographies, Thin-Layer,Thin Layer Chromatographies,Thin-Layer Chromatographies,Thin-Layer Chromatography
D003124 Colorimetry Any technique by which an unknown color is evaluated in terms of standard colors. The technique may be visual, photoelectric, or indirect by means of spectrophotometry. It is used in chemistry and physics. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
D004349 Drug Packaging Containers, packaging, and packaging materials for drugs and BIOLOGICAL PRODUCTS. These include those in ampule, capsule, tablet, solution or other forms. Packaging includes immediate-containers, secondary-containers, and cartons. In the United States, such packaging is controlled under the Federal Food, Drug, and Cosmetic Act which also stipulates requirements for tamper-resistance and child-resistance. Similar laws govern use elsewhere. (From Code of Federal Regulations, 21 CFR 1 Section 210, 1993) DRUG LABELING is also available. Drug Containers and Closures,Packaging, Drug,Drug Containers,Container, Drug,Containers, Drug,Drug Container,Drug Packagings,Packagings, Drug
D004355 Drug Stability The chemical and physical integrity of a pharmaceutical product. Drug Shelf Life,Drugs Shelf Lives,Shelf Life, Drugs,Drug Stabilities,Drugs Shelf Life,Drugs Shelf Live,Life, Drugs Shelf,Shelf Life, Drug,Shelf Live, Drugs,Shelf Lives, Drugs
D005996 Nitroglycerin A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives. Glyceryl Trinitrate,Anginine,Dynamite,Gilustenon,Nitrangin,Nitro-Bid,Nitro-Dur,Nitrocard,Nitroderm,Nitroderm TTS,Nitroglyn,Nitrol,Nitrolan,Nitrong,Nitrospan,Nitrostat,Perlinganit,Susadrin,Sustac,Sustak,Sustonit,Transderm Nitro,Tridil,Trinitrin,Trinitrolong,Nitro Bid,Nitro Dur,NitroBid,NitroDur,Trinitrate, Glyceryl
D000704 Analysis of Variance A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable. ANOVA,Analysis, Variance,Variance Analysis,Analyses, Variance,Variance Analyses
D000814 Aniline Compounds Compounds that include the aminobenzene structure. Phenylamine,Phenylamines,Anilines,Compounds, Aniline

Related Publications

D P Page, and N A Carson, and C A Buhr, and P E Flinn, and C E Wells, and M T Randall
Nitroglycerin sublingual tablets. I. Stability of conventional tablets.
January 1973, Journal of pharmaceutical sciences,
D P Page, and N A Carson, and C A Buhr, and P E Flinn, and C E Wells, and M T Randall
Nitroglycerin sublingual tablets. II. Preparation and stability of a new, stabilized, sublingual, molded nitroglycerin tablet.
December 1973, Journal of pharmaceutical sciences,
D P Page, and N A Carson, and C A Buhr, and P E Flinn, and C E Wells, and M T Randall
Chemical stability of sublingual nitroglycerin tablets carried on paramedic vehicles.
November 1988, The American journal of emergency medicine,
D P Page, and N A Carson, and C A Buhr, and P E Flinn, and C E Wells, and M T Randall
Vapor pressure of nitroglycerin in sublingual molded tablets: implications for stability.
September 1976, Journal of pharmaceutical sciences,
D P Page, and N A Carson, and C A Buhr, and P E Flinn, and C E Wells, and M T Randall
Open-Label Study of the Stability of Sublingual Nitroglycerin Tablets in Simulated Real-Life Conditions.
December 2018, The American journal of cardiology,
D P Page, and N A Carson, and C A Buhr, and P E Flinn, and C E Wells, and M T Randall
Sublingual nitroglycerin. I. Comparative evaluation of the physical stability of commercially available tablets.
December 1988, Pharmaceutisch weekblad. Scientific edition,
D P Page, and N A Carson, and C A Buhr, and P E Flinn, and C E Wells, and M T Randall
Collaborative study of a colorimetric determination of nitroglycerin in sublingual tablets.
January 1972, Journal - Association of Official Analytical Chemists,
D P Page, and N A Carson, and C A Buhr, and P E Flinn, and C E Wells, and M T Randall
Semiautomated method for analysis of nitroglycerin in sublingual tablets: collaborative study.
July 1980, Journal - Association of Official Analytical Chemists,
D P Page, and N A Carson, and C A Buhr, and P E Flinn, and C E Wells, and M T Randall
[The stability of nitroglycerin tablets].
November 1983, Ugeskrift for laeger,
D P Page, and N A Carson, and C A Buhr, and P E Flinn, and C E Wells, and M T Randall
Migraine with aura after administration of sublingual nitroglycerin tablets.
January 2001, Headache,
Copied contents to your clipboard!