Biomaterial Database

[Effect of chlorhexidine gluconate on Serratia marcescens clinical isolates: relevance to serotype O3]. 1994

K Marumo, and Y Nakamura

Department of Clinical Pathology, Showa University Fujigaoka Hospital, Yokohama.

Effect of chlorhexidine gluconate (CHG) on 98 clinical isolates of Serratia marcescens, previously O-serotyped, in The Showa University Fujigaoka Hospital (1989. 1-1991. 3) was investigated. The serotype O3 group (28 strains) was more frequently isolated than any other groups and more resistant to 28 different antimicrobial agents tested. 18 (50%) of 36 strains (MIC of CHG > or = 100 micrograms/ml) were serotype O3 and MIC-distribution of CHG for total O3 strains was more resistant than that for the other serotype strains. Bactericidal effect of CHG on 18 O3 strains (MIC of CHG > or = 100 micrograms/ml) was significantly lower than on the other 10 strains (MIC of CHG < or = 50 micrograms/ml). Although 19 (68%) of total O3 strains were resistant to cefotaxime and the other drugs, MIC-distribution of CHG for these strains was not associated with the antimicrobial resistance tested. The above results, at least, suggest that the serotype O3 group is suited for residing in hospitalized patients more than any other serotype groups.

UI	MeSH Term	Description	Entries
D008826	Microbial Sensitivity Tests	Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).	Bacterial Sensitivity Tests,Drug Sensitivity Assay, Microbial,Minimum Inhibitory Concentration,Antibacterial Susceptibility Breakpoint Determination,Antibiogram,Antimicrobial Susceptibility Breakpoint Determination,Bacterial Sensitivity Test,Breakpoint Determination, Antibacterial Susceptibility,Breakpoint Determination, Antimicrobial Susceptibility,Fungal Drug Sensitivity Tests,Fungus Drug Sensitivity Tests,Sensitivity Test, Bacterial,Sensitivity Tests, Bacterial,Test, Bacterial Sensitivity,Tests, Bacterial Sensitivity,Viral Drug Sensitivity Tests,Virus Drug Sensitivity Tests,Antibiograms,Concentration, Minimum Inhibitory,Concentrations, Minimum Inhibitory,Inhibitory Concentration, Minimum,Inhibitory Concentrations, Minimum,Microbial Sensitivity Test,Minimum Inhibitory Concentrations,Sensitivity Test, Microbial,Sensitivity Tests, Microbial,Test, Microbial Sensitivity,Tests, Microbial Sensitivity
D002710	Chlorhexidine	A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.	Chlorhexidine Acetate,Chlorhexidine Hydrochloride,MK-412A,Novalsan,Sebidin A,Tubulicid,Acetate, Chlorhexidine,Hydrochloride, Chlorhexidine,MK 412A,MK412A
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012703	Serotyping	Process of determining and distinguishing species of bacteria or viruses based on antigens they share.	Serotypings
D012706	Serratia marcescens	A species of gram-negative, facultatively anaerobic, rod-shaped bacteria found in soil, water, food, and clinical specimens. It is a prominent opportunistic pathogen for hospitalized patients.