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Transplantation of islets of Langerhans into the peritoneal cavity of diabetic rats returns the recipients to a normal metabolic state and provides the capability to respond to a glucose stimulation with a rapid release of insulin. Of the two groups of transplanted diabetic rats studied, each had normal nonfasting glucose levels and normal glucose profiles following intravenous glucose tolerance tests. However, one group had significantly lower insulin levels than normal controls both under nonfasting conditions and 4 minutes following glucose stimulation. The other group demonstrated insulin levels greater than those of the normal controls when drawn under nonfasting conditions and essentially identical to the levels of the normal controls following a glucose load. Each transplanted group responded similarly to normal rats with a rapid release of insulin following glucose administration.
M W Steffes, and
D E Sutherland, and
S M Mauer, and
R J Leonard, and
J S Najarian, and
D M Brown
January 1978,
Surgical forum,
M W Steffes, and
D E Sutherland, and
S M Mauer, and
R J Leonard, and
J S Najarian, and
D M Brown
January 1975,
Surgical forum,
M W Steffes, and
D E Sutherland, and
S M Mauer, and
R J Leonard, and
J S Najarian, and
D M Brown
January 1975,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
M W Steffes, and
D E Sutherland, and
S M Mauer, and
R J Leonard, and
J S Najarian, and
D M Brown
January 1992,
Virchows Archiv. B, Cell pathology including molecular pathology,
M W Steffes, and
D E Sutherland, and
S M Mauer, and
R J Leonard, and
J S Najarian, and
D M Brown
October 1976,
Diabetes,
M W Steffes, and
D E Sutherland, and
S M Mauer, and
R J Leonard, and
J S Najarian, and
D M Brown
September 1976,
Urology,
M W Steffes, and
D E Sutherland, and
S M Mauer, and
R J Leonard, and
J S Najarian, and
D M Brown
January 1990,
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes,
M W Steffes, and
D E Sutherland, and
S M Mauer, and
R J Leonard, and
J S Najarian, and
D M Brown
May 2009,
Archives of physiology and biochemistry,
M W Steffes, and
D E Sutherland, and
S M Mauer, and
R J Leonard, and
J S Najarian, and
D M Brown
February 1991,
Diabetologia,
M W Steffes, and
D E Sutherland, and
S M Mauer, and
R J Leonard, and
J S Najarian, and
D M Brown
September 1989,
Diabetes research and clinical practice,
