Biomaterial Database

The influence of long-term administration of Tołpa Peat Preparation on immune reactivity in mice. III. The effect on primary humoral response to sheep erythrocytes. 1993

B Obmińska-Domoradzka, and J Debowy, and T Garbuliński

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Agriculture University, Wrocław, Poland.

Tołpa Peat Preparation (TPP) was administered to mice in daily doses of 1, 10 and 50 mg.kg-1 for 3, 5, 7, 9 or 12 consecutive weeks. After each of the above mentioned periods the primary response to sheep erythrocytes (SRBC) was examined by determination of the percentage of splenocytes forming E rosettes, the number of splenocytes producing anti-SRBC haemolysins of 19S and 7S type, and the level of serum haemagglutinins to SRBC (19S + 7S and 7S types). The effect of enhanced humoral response by TPP was observed in mice immunized with SRBC. This effect depended, first of all on TPP does but also on the duration of time TPP administration. The stimulating effect on the humoral response occurred after the daily dose of 1 mg.kg-1 during 12 weeks. On the other hand, the daily doses of 10 or 50 times higher enhanced the humoral response only during the first 5-7 weeks of TPP administration. Longer administration of TPP in these doses caused disappearance of this effect or reduction of the response to SRBC.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008807	Mice, Inbred BALB C	An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research.	BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D002241	Carbohydrates	A class of organic compounds composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n. The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES.	Carbohydrate
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004338	Drug Combinations	Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.	Drug Combination,Combination, Drug,Combinations, Drug
D005260	Female		Females
D006812	Humic Substances	Organic matter in a state of advanced decay, after passing through the stages of COMPOST and PEAT and before becoming lignite (COAL). It is composed of a heterogenous mixture of compounds including phenolic radicals and acids that polymerize and are not easily separated nor analyzed. (E.A. Ghabbour & G. Davies, eds. Humic Substances, 2001).	Humic Acid,Humic Acids,Humic Substance,Sodium Huminate,Acid, Humic,Acids, Humic,Huminate, Sodium,Substance, Humic,Substances, Humic
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000596	Amino Acids	Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.	Amino Acid,Acid, Amino,Acids, Amino
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia