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Since Lewis rats are susceptible to many inflammatory diseases and have been used in an experimental model of the eosinophilia-myalgia syndrome, we investigated whether Lewis rats would respond to L-tryptophan as have Sprague-Dawley rats reported earlier. In this comparative study using females of both strains, we observed a decrease in the affinity of in vitro L-tryptophan binding to hepatic nuclei and nuclear envelopes of Lewis rats compared with Sprague-Dawley rats. However, in vivo stimulatory effects of administering L-tryptophan on hepatic polyribosomal aggregation, protein synthesis, and nuclear RNA release were similar in both strains. In vitro [3H]tryptophan binding to hepatic nuclear envelopes, using L-tryptophan implicated in cases of the eosinophilia-myalgia syndrome, revealed less specific binding than when using nonimplicated L-tryptophan in both strains. The possible significance of the quantitative difference in the binding affinity of L-tryptophan to hepatic nuclei of Lewis rats compared with those of Sprague-Dawley rats is as yet undetermined.
H Sidransky, and
E Verney
May 2006,
Naunyn-Schmiedeberg's archives of pharmacology,
H Sidransky, and
E Verney
January 2019,
Frontiers in veterinary science,
H Sidransky, and
E Verney
November 1983,
The Journal of investigative dermatology,
H Sidransky, and
E Verney
February 1995,
Behavioral neuroscience,
H Sidransky, and
E Verney
March 2011,
Pharmacology, biochemistry, and behavior,
H Sidransky, and
E Verney
June 1982,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
H Sidransky, and
E Verney
October 2020,
Toxicologic pathology,
H Sidransky, and
E Verney
November 1970,
Archives internationales de pharmacodynamie et de therapie,
H Sidransky, and
E Verney
January 1996,
Drug and chemical toxicology,
H Sidransky, and
E Verney
June 2005,
Physiology & behavior,
