Radiation dose distributions and their optimization. 1975

S Orr

The current situation in the radiotherapy treatment of carcinoma of the larynx is discussed from a physicist's point of view and in the light of the results of one series of patients. The results suggest that the spatial distribution of dose obtainable with supervoltage irradiation for treatment of T1, to T4 No Mo cases is not far from the ideal, and that it is not difficult to prescribe an optimal distribution. A significant difference in the rate of local cure was found between those treated to a CRE value greater than 1,750 and those treated to less than 1,750. Gothenburg results supporting this finding are quoted. Methods are suggested of optimizing the dose distribution in time by increasing the effect on tumor cells without exceeding an acceptable tolerance to normal tissues.

UI MeSH Term Description Entries
D007822 Laryngeal Neoplasms Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS. Cancer of Larynx,Laryngeal Cancer,Larynx Neoplasms,Cancer of the Larynx,Larynx Cancer,Neoplasms, Laryngeal,Cancer, Laryngeal,Cancer, Larynx,Cancers, Laryngeal,Cancers, Larynx,Laryngeal Cancers,Laryngeal Neoplasm,Larynx Cancers,Larynx Neoplasm,Neoplasm, Laryngeal,Neoplasm, Larynx,Neoplasms, Larynx
D011879 Radiotherapy Dosage The total amount of radiation absorbed by tissues as a result of radiotherapy. Dosage, Radiotherapy,Dosages, Radiotherapy,Radiotherapy Dosages
D011882 Radiotherapy, High-Energy Radiotherapy using high-energy (megavolt or higher) ionizing radiation. Types of radiation include gamma rays, produced by a radioisotope within a teletherapy unit; x-rays, electrons, protons, alpha particles (helium ions) and heavy charged ions, produced by particle acceleration; and neutrons and pi-mesons (pions), produced as secondary particles following bombardment of a target with a primary particle. Megavolt Radiotherapy,High-Energy Radiotherapy,Radiotherapy, Megavolt,High Energy Radiotherapy,Radiotherapy, High Energy
D004307 Dose-Response Relationship, Radiation The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation. Dose Response Relationship, Radiation,Dose-Response Relationships, Radiation,Radiation Dose-Response Relationship,Radiation Dose-Response Relationships,Relationship, Radiation Dose-Response,Relationships, Radiation Dose-Response
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

S Orr
September 2005, The British journal of radiology,
S Orr
May 1998, Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al],
S Orr
January 1971, Physics in medicine and biology,
S Orr
January 2015, AJR. American journal of roentgenology,
S Orr
January 2014, Radiologic clinics of North America,
S Orr
April 2006, The British journal of radiology,
S Orr
May 1999, International journal of radiation oncology, biology, physics,
Copied contents to your clipboard!