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This study has investigated the expression of the p53 tumour suppressor gene in 41 cases of primary nasopharyngeal carcinomas (NPC) using the p53 monoclonal antibody BP53-12. Moderate p53 expression was found in 54% and strong expression in 12% of the specimens. There was no correlation between p53 expression and any of the clinicopathological parameters or survival. Surprisingly, three research groups have investigated p53 mutations in NPC and found no fresh tumour specimens to contain p53 mutations in exons 4-8 of the gene. It may be argued that as p53 overexpression has been demonstrated in 70% of the patients investigated in this study, that the mutations lie outside the 4-9 exon region. We are in the process of testing this hypothesis.
M J Porter, and
J K Field, and
J C Lee, and
S F Leung, and
D Lo, and
C A Van Hasselt
January 1967,
Transactions - American Academy of Ophthalmology and Otolaryngology. American Academy of Ophthalmology and Otolaryngology,
M J Porter, and
J K Field, and
J C Lee, and
S F Leung, and
D Lo, and
C A Van Hasselt
July 1994,
Cancer,
M J Porter, and
J K Field, and
J C Lee, and
S F Leung, and
D Lo, and
C A Van Hasselt
March 1994,
Oncogene,
M J Porter, and
J K Field, and
J C Lee, and
S F Leung, and
D Lo, and
C A Van Hasselt
June 1995,
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,
M J Porter, and
J K Field, and
J C Lee, and
S F Leung, and
D Lo, and
C A Van Hasselt
May 1997,
Cancer letters,
M J Porter, and
J K Field, and
J C Lee, and
S F Leung, and
D Lo, and
C A Van Hasselt
November 1998,
The British journal of surgery,
M J Porter, and
J K Field, and
J C Lee, and
S F Leung, and
D Lo, and
C A Van Hasselt
June 1991,
Nature,
M J Porter, and
J K Field, and
J C Lee, and
S F Leung, and
D Lo, and
C A Van Hasselt
September 1997,
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao,
M J Porter, and
J K Field, and
J C Lee, and
S F Leung, and
D Lo, and
C A Van Hasselt
September 1999,
Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology,
M J Porter, and
J K Field, and
J C Lee, and
S F Leung, and
D Lo, and
C A Van Hasselt
December 1985,
National Cancer Institute monograph,
