-transparent.png){kind=logo}
Qualitative and quantitative assays were developed to study the in vitro enzymatic activation of dimethylnitrosamine (DMNA) to its mutagenic form. Three different fractions from mouse liver homogenates, including purified microsomes, were employed for the activation, and several parameters of the assays were investigated. Qualitative tests were conducted to measure the ability of hepatic enzymes obtained from six mammalian species to activate DMNA. A comparison between two inbred mouse strains using the in vitro activation assay demonstrated that this technique might be a useful tool in quantitatively measuring differences in genetically influenced levels of DMNA metabolism in individuals animals and their tissues.
F Gletten, and
U Weekes, and
D Brusick
November 1974,
Mutation research,
F Gletten, and
U Weekes, and
D Brusick
July 1977,
Mutation research,
F Gletten, and
U Weekes, and
D Brusick
February 2003,
Mutation research,
F Gletten, and
U Weekes, and
D Brusick
November 1973,
Cancer research,
F Gletten, and
U Weekes, and
D Brusick
December 1980,
Mutation research,
F Gletten, and
U Weekes, and
D Brusick
October 1991,
Mutation research,
F Gletten, and
U Weekes, and
D Brusick
May 1973,
Mutation research,
F Gletten, and
U Weekes, and
D Brusick
June 1975,
Mutation research,
F Gletten, and
U Weekes, and
D Brusick
September 1991,
Mutagenesis,
F Gletten, and
U Weekes, and
D Brusick
April 1982,
Toxicology letters,
