Clinical evidence for stunned myocardium after coronary artery bypass surgery. 1994

R A Kloner, and K Przyklenk, and G L Kay
Heart Institute, Hospital of the Good Samaritan, Los Angeles, CA 90017.

Stunned myocardium is defined as postischemic dysfunction of viable myocardium. This phenomenon was initially described in animal models of brief ischemia followed by reperfusion, but is becoming increasingly recognized in clinical situations. One of these situations is ventricular dysfunction following coronary artery bypass surgery. Several clinical reports have demonstrated depressed ventricular function in the initial hours after coronary artery bypass surgery: this dysfunction is usually resolved within 24 to 48 hours, and does not appear to be dependent upon alterations in preload, afterload, or temperature. New therapies for improving postischemic myocardial function following cardiopulmonary bypass are under investigation.

UI MeSH Term Description Entries
D006439 Hemodynamics The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM. Hemodynamic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001026 Coronary Artery Bypass Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion. Aortocoronary Bypass,Bypass, Coronary Artery,Bypass Surgery, Coronary Artery,Coronary Artery Bypass Grafting,Coronary Artery Bypass Surgery,Aortocoronary Bypasses,Artery Bypass, Coronary,Artery Bypasses, Coronary,Bypass, Aortocoronary,Bypasses, Aortocoronary,Bypasses, Coronary Artery,Coronary Artery Bypasses
D016277 Ventricular Function, Left The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance. Left Ventricular Function,Function, Left Ventricular,Functions, Left Ventricular,Left Ventricular Functions,Ventricular Functions, Left
D017682 Myocardial Stunning Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity. Hibernation, Myocardial,Myocardial Hibernation,Stunned Myocardium,Myocardium, Stunned,Stunning, Myocardial

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