BIOMAT Database Logo BIOMAT Database Logo

[Myocardial washout of 99mTc-hexakis-2-methoxy isobutyl isonitrile (99mTc-MIBI) at exercise myocardial scintigraphy in patients with ischemic heart disease]. 1994

T Toyama, and T Nishimura, and T Uehara, and T Shimonagata, and K Hayashida, and Y Ishida, and H Nonogi, and K Haze
Department of Tracer Kinetics, Osaka University School of Medicine.

Myocardial washout of the new myocardial perfusion imaging agent, 99mTc-hexakis-2-methoxy isobutyl isonitrile (99mTc-MIBI) was studied in 23 patients with coronary artery disease. These patients were divided into three groups; 8 patients with effort angina pectoris (AP group), 6 with myocardial infarction who had reversible defect (MI-RD (+) group) and 9 with myocardial infarction who had not reversible defect (MI-RD (-) group). Regional radioactivities were determined with postexercise 1- and 3-hour myocardial planar images. In AP group, 99mTc-MIBI washout rate in ischemic area was smaller than in normal area (3.8 +/- 7.5% vs. 8.3 +/- 5.6%, p < 0.05), however, in the remaining two groups, there were no difference in washout between normal and infarct areas. Defect/normal ratios from postexercise 1 hour to 3 hours were slightly increased in AP and MI-RD (+) groups. Our results indicate that 99mTc-MIBI showed slight and incomplete myocardial redistribution in ischemic areas. These data showed to be considered in the interpretation of 99mTc-MIBI myocardial imaging.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009206 Myocardium The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow. Muscle, Cardiac,Muscle, Heart,Cardiac Muscle,Myocardia,Cardiac Muscles,Heart Muscle,Heart Muscles,Muscles, Cardiac,Muscles, Heart
D011877 Radionuclide Imaging The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph. Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D005080 Exercise Test Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used. Arm Ergometry Test,Bicycle Ergometry Test,Cardiopulmonary Exercise Testing,Exercise Testing,Step Test,Stress Test,Treadmill Test,Cardiopulmonary Exercise Test,EuroFit Tests,Eurofit Test Battery,European Fitness Testing Battery,Fitness Testing,Physical Fitness Testing,Arm Ergometry Tests,Bicycle Ergometry Tests,Cardiopulmonary Exercise Tests,Ergometry Test, Arm,Ergometry Test, Bicycle,Ergometry Tests, Arm,Ergometry Tests, Bicycle,EuroFit Test,Eurofit Test Batteries,Exercise Test, Cardiopulmonary,Exercise Testing, Cardiopulmonary,Exercise Tests,Exercise Tests, Cardiopulmonary,Fitness Testing, Physical,Fitness Testings,Step Tests,Stress Tests,Test Battery, Eurofit,Test, Arm Ergometry,Test, Bicycle Ergometry,Test, Cardiopulmonary Exercise,Test, EuroFit,Test, Exercise,Test, Step,Test, Stress,Test, Treadmill,Testing, Cardiopulmonary Exercise,Testing, Exercise,Testing, Fitness,Testing, Physical Fitness,Tests, Arm Ergometry,Tests, Bicycle Ergometry,Tests, Cardiopulmonary Exercise,Tests, EuroFit,Tests, Exercise,Tests, Step,Tests, Stress,Tests, Treadmill,Treadmill Tests
D005260 Female Females
D006321 Heart The hollow, muscular organ that maintains the circulation of the blood. Hearts
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D017202 Myocardial Ischemia A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION). Heart Disease, Ischemic,Ischemia, Myocardial,Ischemic Heart Disease,Disease, Ischemic Heart,Diseases, Ischemic Heart,Heart Diseases, Ischemic,Ischemias, Myocardial,Ischemic Heart Diseases,Myocardial Ischemias

Related Publications

T Toyama, and T Nishimura, and T Uehara, and T Shimonagata, and K Hayashida, and Y Ishida, and H Nonogi, and K Haze
[Thyroid scintigraphy in patients with thyroid tumors using 99mTc-hexakis 2-methoxy isobutyl isonitrile].
November 1994, Kaku igaku. The Japanese journal of nuclear medicine,
T Toyama, and T Nishimura, and T Uehara, and T Shimonagata, and K Hayashida, and Y Ishida, and H Nonogi, and K Haze
99mTc-hexakis methoxy isobutyl isonitrile MIBI scintigraphy and bronchoalveolar fluid lactic dehydrogenase in pulmonary tuberculosis.
January 2008, Hellenic journal of nuclear medicine,
T Toyama, and T Nishimura, and T Uehara, and T Shimonagata, and K Hayashida, and Y Ishida, and H Nonogi, and K Haze
[Clinical evaluation of 99mTc-hexakis 2-methoxy isobutyl isonitrile (MIBI): multicenter phase III clinical trial].
December 1991, Kaku igaku. The Japanese journal of nuclear medicine,
T Toyama, and T Nishimura, and T Uehara, and T Shimonagata, and K Hayashida, and Y Ishida, and H Nonogi, and K Haze
Myocardial clearance of Tc-99m hexakis-2-methoxy-2-methylpropyl isonitrile (MIBI) in patients with coronary artery disease.
May 1990, Clinical nuclear medicine,
T Toyama, and T Nishimura, and T Uehara, and T Shimonagata, and K Hayashida, and Y Ishida, and H Nonogi, and K Haze
99mTc-hexakis methoxy isobutyl isonitrile uptake patterns in nursing mothers and related dosimetry.
January 2008, Hellenic journal of nuclear medicine,
T Toyama, and T Nishimura, and T Uehara, and T Shimonagata, and K Hayashida, and Y Ishida, and H Nonogi, and K Haze
Technetium-99m hexakis 2-methoxy-2-isobutyl isonitrile and thallium-201 extraction, washout, and retention at varying coronary flow rates in rabbit heart.
September 1990, Circulation,
T Toyama, and T Nishimura, and T Uehara, and T Shimonagata, and K Hayashida, and Y Ishida, and H Nonogi, and K Haze
[Comparison of 99mTc-hexakis 2-methoxy-2-isobutyl isonitrile and 201Tl SPECT imaging for evaluation of coronary artery disease].
September 1991, Kaku igaku. The Japanese journal of nuclear medicine,
T Toyama, and T Nishimura, and T Uehara, and T Shimonagata, and K Hayashida, and Y Ishida, and H Nonogi, and K Haze
Myocardial kinetics of 99Tcm hexakis-(2-methoxy-isobutyl-isonitrile) (HMIBI) in patients with coronary heart disease: a comparative study versus 201Tl with SPECT.
January 1988, Nuclear medicine communications,
T Toyama, and T Nishimura, and T Uehara, and T Shimonagata, and K Hayashida, and Y Ishida, and H Nonogi, and K Haze
Segmental analysis of SPECT 99mTc-methoxy isobutyl isonitrile and 201Tl myocardial imaging in ischaemic heart disease.
January 1990, European journal of nuclear medicine,
T Toyama, and T Nishimura, and T Uehara, and T Shimonagata, and K Hayashida, and Y Ishida, and H Nonogi, and K Haze
Quantification of pertechnetate in 99mTc-methoxy isobutyl isonitrile.
September 2008, Nuclear medicine communications,
Copied contents to your clipboard!