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Methotrexate (MTX) is widely accepted as an effective treatment for psoriasis and chronic polyarthrides. We report data from 54 psoriatic polyarthritis patients (354 encounters) treated with MTX. 65% were males, mean age 47.9 years, mean disease duration 9.8 years for arthritis, 14.2 years for psoriasis. The MTX dose was 10-12.5 mg/week. 32 patients are still on MTX after a mean treatment time of 1.6 years. 22 patients discontinued MTX treatment: 11 felt it to be ineffective, in 6 patients there were side effects, 3 patients obtained remission, while 2 patients underwent surgery. Efficacy was good on the whole: number of swollen and tender joints, global disease activity score, ESR, and CRP all underwent a significant reduction. The intake of symptomatic drugs was reduced in 40%. Psoriasis as assessed with the Psoriasis Activity and Severity Index showed a significant improvement. Our data confirm that MTX is of value in most psoriatic polyarthritis patients (60%). In our experience, this drug, gives the maximum efficacy within 6 months of therapy.
P D Pigatto, and
E Gibelli, and
R Ranza, and
A Rossetti
October 1993,
The Journal of rheumatology,
P D Pigatto, and
E Gibelli, and
R Ranza, and
A Rossetti
September 1999,
Presse medicale (Paris, France : 1983),
P D Pigatto, and
E Gibelli, and
R Ranza, and
A Rossetti
January 1966,
Revue francaise d'etudes cliniques et biologiques,
P D Pigatto, and
E Gibelli, and
R Ranza, and
A Rossetti
April 1958,
Zeitschrift fur Rheumaforschung,
P D Pigatto, and
E Gibelli, and
R Ranza, and
A Rossetti
February 1974,
Klinicheskaia meditsina,
P D Pigatto, and
E Gibelli, and
R Ranza, and
A Rossetti
October 2002,
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases,
P D Pigatto, and
E Gibelli, and
R Ranza, and
A Rossetti
August 1963,
British medical journal,
P D Pigatto, and
E Gibelli, and
R Ranza, and
A Rossetti
December 1967,
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris,
P D Pigatto, and
E Gibelli, and
R Ranza, and
A Rossetti
January 2013,
Bulletin of the Hospital for Joint Disease (2013),
P D Pigatto, and
E Gibelli, and
R Ranza, and
A Rossetti
January 2002,
Clinical and experimental rheumatology,
