BIOMAT Database Logo BIOMAT Database Logo

Structure-activity relationships of brassinin in preventing the development of carcinogen-induced mammary lesions in organ culture. 1994

R G Mehta, and J Liu, and A Constantinou, and M Hawthorne, and J M Pezzuto, and R C Moon, and R M Moriarty
Specialized Cancer Center, College of Medicine, University of Illinois at Chicago 60612.

Brassinin, a phytoalexin, is found in Chinese cabbage. Previously, we showed that brassinin significantly inhibited dimethylbenz(a)anthracene (DMBA)-induced mammary lesions in organ culture. Moreover, it was an effective inhibitor against two stage skin carcinogenesis. In the present study, we synthesized several analogs of brassinin and evaluated their effectiveness in the mouse mammary gland organ culture model. Results showed that cyclobrassinin, also a naturally occurring brassinin analog, was more effective than brassinin. Spirobrassinin and N-ethyl-2,3-dihydrobrassinin also significantly inhibited mammary lesion formation. However, none of the methyl substituted analogs were effective. The effects of brassinin may, in part, be mediated by induction of phase II detoxifying enzymes such as quinone reductase.

UI MeSH Term Description Entries
D007211 Indoles Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
D008321 Mammary Glands, Animal MAMMARY GLANDS in the non-human MAMMALS. Mammae,Udder,Animal Mammary Glands,Animal Mammary Gland,Mammary Gland, Animal,Udders
D008807 Mice, Inbred BALB C An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D009924 Organ Culture Techniques A technique for maintenance or growth of animal organs in vitro. It refers to three-dimensional cultures of undisaggregated tissue retaining some or all of the histological features of the tissue in vivo. (Freshney, Culture of Animal Cells, 3d ed, p1) Organ Culture,Culture Technique, Organ,Culture Techniques, Organ,Organ Culture Technique,Organ Cultures
D010936 Plant Extracts Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard. Herbal Medicines,Plant Extract,Extract, Plant,Extracts, Plant,Medicines, Herbal
D005260 Female Females
D000094162 Phytoalexins Secondary metabolites produced and accumulated by plants infected with microbial pathogen or otherwise under abiotic stress. Phytoalexins are structurally diverse but in common play a role in triggering PLANT SYSTEMIC ACQUIRED RESISTANCE. Diterpenoid Phytoalexins,Flavonoid Phytoalexins,Indole Phytoalexins,Isoflavonoid Phytoalexins,Phytoalexin Metabolites,Sesquiterpene Phytoalexins,Terpenoid Phytoalexins,Metabolites, Phytoalexin,Phytoalexins, Diterpenoid,Phytoalexins, Flavonoid,Phytoalexins, Indole,Phytoalexins, Isoflavonoid,Phytoalexins, Sesquiterpene,Phytoalexins, Terpenoid
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012717 Sesquiterpenes Fifteen-carbon compounds formed from three isoprenoid units with general formula C15H24. Farnesanes,Farnesene,Farnesenes,Sesquiterpene,Sesquiterpene Derivatives,Sesquiterpenoid,Sesquiterpenoids,Derivatives, Sesquiterpene
D013329 Structure-Activity Relationship The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships

Related Publications

R G Mehta, and J Liu, and A Constantinou, and M Hawthorne, and J M Pezzuto, and R C Moon, and R M Moriarty
Effects of 12-O-tetradecanoylphorbol-13-acetate on carcinogen-induced mouse mammary lesions in organ culture.
November 1986, Cancer research,
R G Mehta, and J Liu, and A Constantinou, and M Hawthorne, and J M Pezzuto, and R C Moon, and R M Moriarty
Organ culture passage enhances the oncogenicity of carcinogen-induced hyperplastic mammary nodules.
February 1981, In vitro,
R G Mehta, and J Liu, and A Constantinou, and M Hawthorne, and J M Pezzuto, and R C Moon, and R M Moriarty
Chemical carcinogen-induced alveolar nodules in organ culture of mouse mammary gland.
November 1974, Journal of the National Cancer Institute,
R G Mehta, and J Liu, and A Constantinou, and M Hawthorne, and J M Pezzuto, and R C Moon, and R M Moriarty
Cell cycle-related hormone carcinogen interaction during chemical carcinogen induction of nodule-like mammary lesions in organ culture.
May 1976, Cancer research,
R G Mehta, and J Liu, and A Constantinou, and M Hawthorne, and J M Pezzuto, and R C Moon, and R M Moriarty
25-Hydroxyvitamin D3 is a natural chemopreventive agent against carcinogen induced precancerous lesions in mouse mammary gland organ culture.
January 2009, Breast cancer research and treatment,
R G Mehta, and J Liu, and A Constantinou, and M Hawthorne, and J M Pezzuto, and R C Moon, and R M Moriarty
Structure-activity relationships of retinoids in hamster tracheal organ culture.
October 1980, Cancer research,
R G Mehta, and J Liu, and A Constantinou, and M Hawthorne, and J M Pezzuto, and R C Moon, and R M Moriarty
Fine structure of murine pulmonary adenomata induced by carcinogen treatment in organ culture.
October 1969, Cancer research,
R G Mehta, and J Liu, and A Constantinou, and M Hawthorne, and J M Pezzuto, and R C Moon, and R M Moriarty
Fatty acid-induced modifications of mouse mammary alveolar lesions in organ culture.
September 1984, Carcinogenesis,
R G Mehta, and J Liu, and A Constantinou, and M Hawthorne, and J M Pezzuto, and R C Moon, and R M Moriarty
Pulmonary adenomata induced by carcinogen treatment in organ culture.
September 1966, British journal of cancer,
R G Mehta, and J Liu, and A Constantinou, and M Hawthorne, and J M Pezzuto, and R C Moon, and R M Moriarty
Pulmonary adenomata induced by carcinogen treatment in organ culture. Influence of increasing amounts of carcinogen.
December 1970, British journal of cancer,
Copied contents to your clipboard!