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A series of substituted 2-acylpyridine-alpha-(N)-hetarylhydrazones was prepared and studied for their effects on mammalian ribonucleotide reductase activity using a highly purified enzyme preparation from Ehrlich tumor cells and on mouse leukemia L1210 cell growth in culture. Pyridine-2-aldehyde-2-pyridylhydrazone (PH 22), ethyl-2-pyridylketone-I-phthalazinylhydrazone (PH 22-25) and pyridine-2-aldehyde-2'-quinolylhydrazone (PQ 22) inhibited purified ribonucleotide reductase activity and inhibited L1210 cell growth in culture. PH 22-25 inhibited [3H]thymidine incorporation into DNA and inhibited ribonucleotide reductase activity in situ (as measured bvy [14C]cytidine metabolism and as a result inhibited DNA synthesis. There was no effect on RNA synthesis. These data indicate that these substituted hydrazones are potent inhibitors of tumor cell growth through the inhibition of ribonucleotide reductase.
J G Cory, and
D L Downes, and
A H Cory, and
K J Schaper, and
J K Seydel
January 1993,
Advances in enzyme regulation,
J G Cory, and
D L Downes, and
A H Cory, and
K J Schaper, and
J K Seydel
August 1985,
Biochemical pharmacology,
J G Cory, and
D L Downes, and
A H Cory, and
K J Schaper, and
J K Seydel
February 1988,
Cancer research,
J G Cory, and
D L Downes, and
A H Cory, and
K J Schaper, and
J K Seydel
June 1988,
Cancer letters,
J G Cory, and
D L Downes, and
A H Cory, and
K J Schaper, and
J K Seydel
June 1988,
Journal of the National Cancer Institute,
J G Cory, and
D L Downes, and
A H Cory, and
K J Schaper, and
J K Seydel
January 1989,
Journal of medicinal chemistry,
J G Cory, and
D L Downes, and
A H Cory, and
K J Schaper, and
J K Seydel
February 1987,
Cancer research,
J G Cory, and
D L Downes, and
A H Cory, and
K J Schaper, and
J K Seydel
January 1989,
Advances in enzyme regulation,
J G Cory, and
D L Downes, and
A H Cory, and
K J Schaper, and
J K Seydel
July 2019,
Nature communications,
J G Cory, and
D L Downes, and
A H Cory, and
K J Schaper, and
J K Seydel
January 2003,
Nucleosides, nucleotides & nucleic acids,
