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Resistance of Friend murine erythroleukemia cells was induced or selected by continuous stepwise exposure to adriamycin (ADM). The resistance index (R.I.) varied with different "mdr type" drugs, even when the compounds were closely related as ADM and daunorubicin (DNR). The cell uptake of anthracycline, evaluated by flow cytometry (FCM), was better correlated with the R.I. than the HPLC assessment. The quantitative cytology showed nuclear changes (size and color distribution); all the modifications were in part dependent on the degree of resistance. This study showed that the graded resistant sublines differed in their resistant phenotypes apart from their different degree of resistance.
B Desoize, and
C Broglio, and
M C Gorisse, and
F Briois, and
Y Carpentier, and
C Delvincourt, and
J Dufer
January 1986,
Leukemia research,
B Desoize, and
C Broglio, and
M C Gorisse, and
F Briois, and
Y Carpentier, and
C Delvincourt, and
J Dufer
July 1994,
International journal of oncology,
B Desoize, and
C Broglio, and
M C Gorisse, and
F Briois, and
Y Carpentier, and
C Delvincourt, and
J Dufer
December 1984,
Cancer research,
B Desoize, and
C Broglio, and
M C Gorisse, and
F Briois, and
Y Carpentier, and
C Delvincourt, and
J Dufer
June 1985,
Cancer research,
B Desoize, and
C Broglio, and
M C Gorisse, and
F Briois, and
Y Carpentier, and
C Delvincourt, and
J Dufer
October 1982,
Biochemical pharmacology,
B Desoize, and
C Broglio, and
M C Gorisse, and
F Briois, and
Y Carpentier, and
C Delvincourt, and
J Dufer
June 1979,
Cancer research,
B Desoize, and
C Broglio, and
M C Gorisse, and
F Briois, and
Y Carpentier, and
C Delvincourt, and
J Dufer
April 1981,
Chemico-biological interactions,
B Desoize, and
C Broglio, and
M C Gorisse, and
F Briois, and
Y Carpentier, and
C Delvincourt, and
J Dufer
January 1974,
Hereditas,
B Desoize, and
C Broglio, and
M C Gorisse, and
F Briois, and
Y Carpentier, and
C Delvincourt, and
J Dufer
January 1978,
Biochemical pharmacology,
B Desoize, and
C Broglio, and
M C Gorisse, and
F Briois, and
Y Carpentier, and
C Delvincourt, and
J Dufer
July 1986,
Japanese journal of cancer research : Gann,
