-transparent.png){kind=logo}
The alpha 1 subunit of cardiac Ca2+ channel, expressed alone or coexpressed with the corresponding beta subunit in Xenopus laevis oocytes, elicits rapidly inactivating Ca2+ currents. The inactivation has the following properties: 1) It is practically absent in external Ba2+; 2) it increases with Ca2+ current amplitudes; 3) it is faster at more negative potentials for comparable Ca2+ current amplitudes; 4) it is independent of channel density; and 5) it does not require the beta subunit. These findings indicate that the Ca2+ binding site responsible for inactivation is encoded in the alpha 1 subunit and suggest that it is located near the inner channel mouth but outside the membrane electric field.
A Neely, and
R Olcese, and
X Wei, and
L Birnbaumer, and
E Stefani
June 1995,
The Journal of physiology,
A Neely, and
R Olcese, and
X Wei, and
L Birnbaumer, and
E Stefani
October 1992,
The Journal of membrane biology,
A Neely, and
R Olcese, and
X Wei, and
L Birnbaumer, and
E Stefani
October 1997,
The Journal of general physiology,
A Neely, and
R Olcese, and
X Wei, and
L Birnbaumer, and
E Stefani
October 1990,
The Journal of general physiology,
A Neely, and
R Olcese, and
X Wei, and
L Birnbaumer, and
E Stefani
September 1998,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
A Neely, and
R Olcese, and
X Wei, and
L Birnbaumer, and
E Stefani
January 1996,
FEBS letters,
A Neely, and
R Olcese, and
X Wei, and
L Birnbaumer, and
E Stefani
October 1992,
Biochimica et biophysica acta,
A Neely, and
R Olcese, and
X Wei, and
L Birnbaumer, and
E Stefani
February 1992,
Biochemical and biophysical research communications,
A Neely, and
R Olcese, and
X Wei, and
L Birnbaumer, and
E Stefani
November 1999,
The Journal of pharmacology and experimental therapeutics,
A Neely, and
R Olcese, and
X Wei, and
L Birnbaumer, and
E Stefani
February 2000,
British journal of pharmacology,
