-transparent.png){kind=logo}
A cDNA coding for a human type VIII adenylyl cyclase has been isolated from human newborn brain-stem tissue. This cDNA is 6,005 bp long and encodes for a protein of 1251 amino acids, exhibiting the two sets of six transmembrane spanning regions and the hydrophobicity profile typical of other mammalian adenylyl cyclases. Comparison with the rat form shows that they share 97% identity in amino acids. Type VIII adenylyl cyclase is unique in that it has both a long carboxy terminal and a long amino terminal tail. This is the first report on a complete cDNA clone coding for a human adenylyl cyclase. The distribution and regulation of this particular adenylyl cyclase suggest that it may be involved in learning, in memory and in drug dependence.
N Defer, and
O Marinx, and
D Stengel, and
A Danisova, and
V Iourgenko, and
I Matsuoka, and
D Caput, and
J Hanoune
March 1999,
The Journal of biological chemistry,
N Defer, and
O Marinx, and
D Stengel, and
A Danisova, and
V Iourgenko, and
I Matsuoka, and
D Caput, and
J Hanoune
June 2005,
American journal of physiology. Cell physiology,
N Defer, and
O Marinx, and
D Stengel, and
A Danisova, and
V Iourgenko, and
I Matsuoka, and
D Caput, and
J Hanoune
February 1994,
FEBS letters,
N Defer, and
O Marinx, and
D Stengel, and
A Danisova, and
V Iourgenko, and
I Matsuoka, and
D Caput, and
J Hanoune
January 1999,
Biochemical and biophysical research communications,
N Defer, and
O Marinx, and
D Stengel, and
A Danisova, and
V Iourgenko, and
I Matsuoka, and
D Caput, and
J Hanoune
May 1998,
Genomics,
N Defer, and
O Marinx, and
D Stengel, and
A Danisova, and
V Iourgenko, and
I Matsuoka, and
D Caput, and
J Hanoune
May 1993,
Genomics,
N Defer, and
O Marinx, and
D Stengel, and
A Danisova, and
V Iourgenko, and
I Matsuoka, and
D Caput, and
J Hanoune
September 2000,
Biochimica et biophysica acta,
N Defer, and
O Marinx, and
D Stengel, and
A Danisova, and
V Iourgenko, and
I Matsuoka, and
D Caput, and
J Hanoune
January 2002,
Methods in enzymology,
N Defer, and
O Marinx, and
D Stengel, and
A Danisova, and
V Iourgenko, and
I Matsuoka, and
D Caput, and
J Hanoune
July 2000,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
N Defer, and
O Marinx, and
D Stengel, and
A Danisova, and
V Iourgenko, and
I Matsuoka, and
D Caput, and
J Hanoune
January 2006,
Cellular signalling,
