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Glomerulonephritis in idiopatic mixed cryoglobulinemia represents perhaps a glomerular damage by immune complexes. In this study, a sigmoidal-like curve was obtained after addition of 13 different mixed cryoglobulins to both autologous and isologous platelet-rich plasma, tested in platelet aggregometer. The lag phase of the curve corresponds to platelet phagocytosis of cryoglobulin-binding ferritin, as shown in electron microscopy and the optical density decrease phase corresponds to the aggregation of platelets that shows the same ultrastructural characteristics of ADP-induced platelet aggregation. This platelet aggregation is inhibited by different drugs. Intraglomerular platelet aggregation by cryoglobulins might play a key role in determining the glomerular damage in cryoglobulinemia by the release of nucleotides and vasoactive amines.
M Cortellaro, and
G Lambertenghi-Deliliers, and
E Cofrancesco, and
E Pogliani, and
E Pozzoli, and
E Imbasciati, and
C Praga
December 1968,
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March 1991,
Pathologie-biologie,
M Cortellaro, and
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January 1984,
British journal of clinical practice. Supplement,
M Cortellaro, and
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C Praga
April 2000,
Thrombosis research,
M Cortellaro, and
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E Cofrancesco, and
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C Praga
September 2013,
Life sciences,
M Cortellaro, and
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C Praga
November 1977,
Prostaglandins,
M Cortellaro, and
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C Praga
August 1985,
Thrombosis and haemostasis,
M Cortellaro, and
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E Cofrancesco, and
E Pogliani, and
E Pozzoli, and
E Imbasciati, and
C Praga
January 2007,
Journal of molecular recognition : JMR,
M Cortellaro, and
G Lambertenghi-Deliliers, and
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E Pozzoli, and
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C Praga
January 1977,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
M Cortellaro, and
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January 1992,
International archives of allergy and immunology,
