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The molecular interaction of various sulfones and sulfonamides with partially purified dihydropteroate synthetase from Neisseria meningitidis M-166 has been examined. The mode of action of the sulfones was similar to that of the sulfonamides. Both groups of drugs were competitive inhibitors of dihydropteroate synthetase with respect to p-aminobenzoate in a partially purified enzyme preparation. 4,4'-Diaminodiphenylsulfone was three times more effective than sulfadiazine and nine times more effective than sulfanilamide as a competitive inhibitor of dihydropteroate synthetase. The inhibitory activity of 4-amino-4'-acetamidodiphenylsulfone and 4-amino-4'-formamidodiphenylsulfone in this system eliminated their prior conversion to 4,4'-diaminodiphenylsulfone as a requirement for activity.
R I Ho, and
L Corman, and
S A Mores, and
H Schneider
June 1973,
Antimicrobial agents and chemotherapy,
R I Ho, and
L Corman, and
S A Mores, and
H Schneider
March 1987,
Journal of medicinal chemistry,
R I Ho, and
L Corman, and
S A Mores, and
H Schneider
July 1982,
Journal of pharmaceutical sciences,
R I Ho, and
L Corman, and
S A Mores, and
H Schneider
September 1950,
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris,
R I Ho, and
L Corman, and
S A Mores, and
H Schneider
June 1994,
The Journal of infectious diseases,
R I Ho, and
L Corman, and
S A Mores, and
H Schneider
December 1951,
Gazette medicale de France,
R I Ho, and
L Corman, and
S A Mores, and
H Schneider
November 1961,
Arzneimittel-Forschung,
R I Ho, and
L Corman, and
S A Mores, and
H Schneider
March 1952,
Clinica latina,
R I Ho, and
L Corman, and
S A Mores, and
H Schneider
October 1950,
A Gyogyszeresz,
R I Ho, and
L Corman, and
S A Mores, and
H Schneider
October 1987,
Antimicrobial agents and chemotherapy,
