BIOMAT Database Logo BIOMAT Database Logo

High levels of viral replication during acute hepatitis B infection predict progression to chronicity. 1994

T L Fong, and A M Di Bisceglie, and R Biswas, and J G Waggoner, and L Wilson, and J Claggett, and J H Hoofnagle
Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.

To assess the pattern of development of serologic markers during acute hepatitis B, levels of HBsAg, HBeAg, and hepatitis B virus (HBV) DNA were assayed in stored serum samples obtained sequentially from 12 subjects infected with HBV during experimental studies conducted in the 1950s. Six patients developed acute self-limited hepatitis, three developed chronic hepatitis, and three had an asymptomatic infection without HBsAg. HBsAg was the first serologic marker detected (mean = 52 days after exposure), followed by HBeAg (62 days) and HBV DNA (72 days). Peak HBsAg levels occurred before onset of symptoms and correlated with peak titers of HBeAg and HBV DNA. Patients who developed chronic hepatitis had higher peak levels of viral markers than those with self-limited disease: HBsAg (30 versus 5.4 micrograms/ml), HBeAg (1:2,000 versus 1:60 titer) and HBV DNA (3,192 versus 444 pg/ml). Thus, chronic HBV infection is characterized by high levels of viral replication appearing early during the acute phase of infection.

UI MeSH Term Description Entries
D008297 Male Males
D002908 Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2). Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic
D004279 DNA, Viral Deoxyribonucleic acid that makes up the genetic material of viruses. Viral DNA
D006509 Hepatitis B INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact. Hepatitis B Virus Infection
D006513 Hepatitis B e Antigens A closely related group of antigens found in the plasma only during the infective phase of hepatitis B or in virulent chronic hepatitis B, probably indicating active virus replication; there are three subtypes which may exist in a complex with immunoglobulins G. HBeAg,Hepatitis B e Antigen,Hepatitis Be Antigen,e Antigen,e Antigens,HBe Ag-1,HBe Ag-2,Hepatitis Be Antigens,Antigen, Hepatitis Be,Antigen, e,Antigens, Hepatitis Be,Antigens, e,Be Antigen, Hepatitis,Be Antigens, Hepatitis
D006514 Hepatitis B Surface Antigens Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen. Australia Antigen,HBsAg,Hepatitis B Surface Antigen,Antigen, Australia
D006515 Hepatitis B virus The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum. Dane Particle,Hepatitis Virus, Homologous Serum,B virus, Hepatitis,Hepatitis B viruses,Particle, Dane,viruses, Hepatitis B
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000208 Acute Disease Disease having a short and relatively severe course. Acute Diseases,Disease, Acute,Diseases, Acute
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor

Related Publications

T L Fong, and A M Di Bisceglie, and R Biswas, and J G Waggoner, and L Wilson, and J Claggett, and J H Hoofnagle
Predicting progression of acute type-B hepatitis to chronicity.
August 1976, Lancet (London, England),
T L Fong, and A M Di Bisceglie, and R Biswas, and J G Waggoner, and L Wilson, and J Claggett, and J H Hoofnagle
Detection of hepatitis B virus DNA levels in predicting the chronicity of acute viral hepatitis, type B.
January 1986, Hepatology (Baltimore, Md.),
T L Fong, and A M Di Bisceglie, and R Biswas, and J G Waggoner, and L Wilson, and J Claggett, and J H Hoofnagle
Acute viral hepatitis B in children: lack of chronicity.
August 1990, Lancet (London, England),
T L Fong, and A M Di Bisceglie, and R Biswas, and J G Waggoner, and L Wilson, and J Claggett, and J H Hoofnagle
Serum immunoglobulin levels during acute viral B hepatitis.
January 1983, Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten,
T L Fong, and A M Di Bisceglie, and R Biswas, and J G Waggoner, and L Wilson, and J Claggett, and J H Hoofnagle
Viral replication in chronic hepatitis B virus infection.
November 1983, Digestive diseases and sciences,
T L Fong, and A M Di Bisceglie, and R Biswas, and J G Waggoner, and L Wilson, and J Claggett, and J H Hoofnagle
Role of delta infection in the progression to chronicity of acute HBsAg positive hepatitis.
January 1984, Gastroenterologie clinique et biologique,
T L Fong, and A M Di Bisceglie, and R Biswas, and J G Waggoner, and L Wilson, and J Claggett, and J H Hoofnagle
Risks of chronicity following acute hepatitis B virus infection: a review.
April 1995, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
T L Fong, and A M Di Bisceglie, and R Biswas, and J G Waggoner, and L Wilson, and J Claggett, and J H Hoofnagle
Do high levels of viral replication contribute to fulminant hepatitis A?
February 2005, Liver international : official journal of the International Association for the Study of the Liver,
T L Fong, and A M Di Bisceglie, and R Biswas, and J G Waggoner, and L Wilson, and J Claggett, and J H Hoofnagle
Characteristics of the early phase of chronicity in acute hepatitis B infection.
April 1999, Journal of medical virology,
T L Fong, and A M Di Bisceglie, and R Biswas, and J G Waggoner, and L Wilson, and J Claggett, and J H Hoofnagle
Hepatitis B virus core-related antigen levels predict progression to liver cirrhosis in hepatitis B carriers.
April 2018, Journal of gastroenterology and hepatology,
Copied contents to your clipboard!