BIOMAT Database Logo BIOMAT Database Logo

[A case of anti-glomerular basement membrane antibody (AGBMA) nephritis associated with myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)]. 1994

O Tamai, and Y Hori, and K Kouno, and J Egami, and A Oohara, and H Matsuoka, and K Majima, and H Nishida, and E Higuchi, and M Morimatsu
Third Department of Internal Medicine, Kurume University School of Medicine, Fukuoka, Japan.

A 68-year-old patient visited our hospital, because of progressive renal failure. Laboratory data were serum creatinine 13.3 mg/dl, BUN 74.3 mg/dl, AGBMA 134U, MPO-ANCA 37% and CIC 1.6 g/dl. Hemodialysis was performed on admission and renal biopsy was conducted. Though the histological findings showed fibrocellular crescents and global sclerosis in many glomeruli, renal function was gradually ameliorated by administration of prednisolone (40 mg/day) and cyclophosphamide (50 mg/day). After 3 weeks of therapy, hemodialysis was withdrawn temporarily. Because of the complication of pneumocystis carini, prednisolone and cyclophosphamide were discontinued, and maintenance hemodialysis was resumed. In spite of progressed histological findings, hemodialysis was withdrawn at least temporarily through the use of pharmacological therapy. Thus, the presence of ANCA may indicate a relatively good prognosis of AGBMA nephritis.

UI MeSH Term Description Entries
D007678 Kidney Glomerulus A cluster of convoluted capillaries beginning at each nephric tubule in the kidney and held together by connective tissue. Glomerulus, Kidney
D008297 Male Males
D009195 Peroxidase A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC 1.11.1.7. Myeloperoxidase,Hemi-Myeloperoxidase,Hemi Myeloperoxidase
D011239 Prednisolone A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states. Di-Adreson-F,Predate,Predonine,Di Adreson F,DiAdresonF
D003520 Cyclophosphamide Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer. (+,-)-2-(bis(2-Chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-Oxide Monohydrate,B-518,Cyclophosphamide Anhydrous,Cyclophosphamide Monohydrate,Cyclophosphamide, (R)-Isomer,Cyclophosphamide, (S)-Isomer,Cyclophosphane,Cytophosphan,Cytophosphane,Cytoxan,Endoxan,NSC-26271,Neosar,Procytox,Sendoxan,B 518,B518,NSC 26271,NSC26271
D005921 Glomerulonephritis Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY. Bright Disease,Kidney Scarring,Glomerulonephritides,Scarring, Kidney
D006435 Renal Dialysis Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION. Dialysis, Extracorporeal,Dialysis, Renal,Extracorporeal Dialysis,Hemodialysis,Dialyses, Extracorporeal,Dialyses, Renal,Extracorporeal Dialyses,Hemodialyses,Renal Dialyses
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D001323 Autoantibodies Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them. Autoantibody

Related Publications

O Tamai, and Y Hori, and K Kouno, and J Egami, and A Oohara, and H Matsuoka, and K Majima, and H Nishida, and E Higuchi, and M Morimatsu
[A case of progressive systemic sclerosis with crescentic glomerulonephritis associated with myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) and anti-glomerular basement membrane antibody (anti-GBM Ab)].
March 1995, Nihon Jinzo Gakkai shi,
O Tamai, and Y Hori, and K Kouno, and J Egami, and A Oohara, and H Matsuoka, and K Majima, and H Nishida, and E Higuchi, and M Morimatsu
[Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) -associated glomerulonephritis with acute pancreatitis: a case report].
January 2015, Nihon Jinzo Gakkai shi,
O Tamai, and Y Hori, and K Kouno, and J Egami, and A Oohara, and H Matsuoka, and K Majima, and H Nishida, and E Higuchi, and M Morimatsu
Rheumatoid arthritis complicated with myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis: a case report.
January 2005, Modern rheumatology,
O Tamai, and Y Hori, and K Kouno, and J Egami, and A Oohara, and H Matsuoka, and K Majima, and H Nishida, and E Higuchi, and M Morimatsu
[A case of myeloperoxidase-specific antineutrophil cytoplasmic antibody (MPO-ANCA)-related glomerulonephritis associated with Cogan's syndrome].
September 1996, Nihon Jinzo Gakkai shi,
O Tamai, and Y Hori, and K Kouno, and J Egami, and A Oohara, and H Matsuoka, and K Majima, and H Nishida, and E Higuchi, and M Morimatsu
[A case of microscopic polyarteritis nodosa associated with myeloperoxidase-antineutrophil cytoplasmic autoantibodies (MPO-ANCA)].
June 1992, Nihon Jinzo Gakkai shi,
O Tamai, and Y Hori, and K Kouno, and J Egami, and A Oohara, and H Matsuoka, and K Majima, and H Nishida, and E Higuchi, and M Morimatsu
Infection-induced myeloperoxidase specific antineutrophil cytoplasmic antibody (MPO-ANCA) associated vasculitis: A systematic review.
November 2020, Clinical immunology (Orlando, Fla.),
O Tamai, and Y Hori, and K Kouno, and J Egami, and A Oohara, and H Matsuoka, and K Majima, and H Nishida, and E Higuchi, and M Morimatsu
The Sequential Development of Antiglomerular Basement Membrane Nephritis and Myeloperoxidase-antineutrophil Cytoplasmic Antibody-associated Vasculitis.
October 2017, Internal medicine (Tokyo, Japan),
O Tamai, and Y Hori, and K Kouno, and J Egami, and A Oohara, and H Matsuoka, and K Majima, and H Nishida, and E Higuchi, and M Morimatsu
Epstein-Barr virus reactivation induced myeloperoxidase-specific antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis.
October 2021, BMJ case reports,
O Tamai, and Y Hori, and K Kouno, and J Egami, and A Oohara, and H Matsuoka, and K Majima, and H Nishida, and E Higuchi, and M Morimatsu
Antineutrophil cytoplasmic autoantibodies with myeloperoxidase specificity in a patient with anti-glomerular basement membrane disease.
July 1995, The Netherlands journal of medicine,
O Tamai, and Y Hori, and K Kouno, and J Egami, and A Oohara, and H Matsuoka, and K Majima, and H Nishida, and E Higuchi, and M Morimatsu
Myeloperoxidase Antineutrophil Cytoplasmic Antibody (MPO-ANCA) Associated Crescentic and Necrotizing Glomerulonephritis (GN) with Membranoproliferative GN Features.
January 2016, Internal medicine (Tokyo, Japan),
Copied contents to your clipboard!