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Adenosine has excitatory actions on neurotransmission in the superior colliculus. To investigate whether adenosine A1 or A2 receptors are involved in mediating these excitatory actions, the effect of A1 and A2 receptor agonists and antagonists on the evoked postsynaptic potentials (PSP) in the superficial grey layer were tested using slices of the superior colliculus. Application of both A1 agonists, such as CHA, R-PIA, and the A2 agonist, CGS-21680 increased the amplitude of the PSP. The increase in PSP amplitude occurred gradually over 20-30 min after application of these adenosine agonists. Application of the A1 antagonist 8-CPT, and the A2 antagonists, DMPX and CGS-15943, increased the amplitude of the PSP and could not antagonize the excitatory effect of adenosine. These results suggest that the mechanism of the excitatory effect of adenosine cannot be explained by the classical concept of A1 and A2 adenosine receptor subtypes which were identified by their effect on adenylate cyclase activity.
A Ishikawa, and
E Kurihara, and
Y Okada
December 1990,
Neuroscience letters,
A Ishikawa, and
E Kurihara, and
Y Okada
August 1990,
Brain research,
A Ishikawa, and
E Kurihara, and
Y Okada
December 1994,
Neuroscience letters,
A Ishikawa, and
E Kurihara, and
Y Okada
May 1991,
European journal of pharmacology,
A Ishikawa, and
E Kurihara, and
Y Okada
May 1992,
Neuroscience letters,
A Ishikawa, and
E Kurihara, and
Y Okada
November 1994,
Neuroscience letters,
A Ishikawa, and
E Kurihara, and
Y Okada
November 2000,
Clinical and experimental pharmacology & physiology,
A Ishikawa, and
E Kurihara, and
Y Okada
April 1999,
Neuroscience letters,
A Ishikawa, and
E Kurihara, and
Y Okada
January 1999,
Fundamental & clinical pharmacology,
A Ishikawa, and
E Kurihara, and
Y Okada
January 1982,
Archives internationales de pharmacodynamie et de therapie,
