-transparent.png){kind=logo}
The effects of the immunosuppressive agent cyclosporin A (CsA) after 4, 8, 15, and 21 days of treatment were investigated in the thymus of 12 week-old rats by an immunochemical method using the TRPM1 and TRPM2 monoclonal antibodies. Major changes were not observed after 4, 8 and 15 days' treatment. But thymus histology completely changed after 21 days: Interdigitating (TRPM1-positive) cells completely disappeared and only a small number of (TRPM1-positive) macrophages were observed in the thymus cortex. TRPM2-positive cells also decreased, most markedly in the outer cortex and cortex. These findings indicate that inhibition of T-lymphocyte maturation is linked to disappearance of interdigitating cells which produce cytokines with proliferative and differentiation properties.
R Rezzani, and
L Rodella, and
G Corsetti, and
R G Ventura
January 1989,
Virchows Archiv. B, Cell pathology including molecular pathology,
R Rezzani, and
L Rodella, and
G Corsetti, and
R G Ventura
January 1990,
Thymus,
R Rezzani, and
L Rodella, and
G Corsetti, and
R G Ventura
August 1993,
Thymus,
R Rezzani, and
L Rodella, and
G Corsetti, and
R G Ventura
January 1992,
Journal of comparative pathology,
R Rezzani, and
L Rodella, and
G Corsetti, and
R G Ventura
January 1986,
Thymus,
R Rezzani, and
L Rodella, and
G Corsetti, and
R G Ventura
January 1993,
Advances in experimental medicine and biology,
R Rezzani, and
L Rodella, and
G Corsetti, and
R G Ventura
November 1992,
Thymus,
R Rezzani, and
L Rodella, and
G Corsetti, and
R G Ventura
July 1981,
Agents and actions,
R Rezzani, and
L Rodella, and
G Corsetti, and
R G Ventura
December 1971,
Revista brasileira de biologia,
R Rezzani, and
L Rodella, and
G Corsetti, and
R G Ventura
December 1989,
Archives of dermatology,
