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In 6 cases initially showing a symptomatology of erythroleukemia, the proliferation of erythroblasts was studied by combined Feulgen cytophotometry and autoradiography after labelling with 3H-TdR in vivo. A proliferation disturbance was observed consisting of an accumulation of diploid and unlabelled cells and a decreased proportion of cells in S. This defect occurred within the basophilic cell compartment in one case and within the early polychromatic cell compartment in all 6 cases. The results indicate the existence of out-of-cycle cells, which may be responsible for the inefficacy for erythropoiesis in this disease. The defect was present in all 4 cases with acute erythroleukaemia. In one of the two cases showing no deterioration of the physical and haematological condition over a period of years, an additional defect was observed, consisting of a striking accumulation of tetraploid unlabelled cells. Therefore, the technique used may be suitable as a diagnostic tool for evaluation of new types of ineffective erythropoiesis.
W Queisser, and
U Pepperl, and
U Kempgens, and
U Müller
June 1964,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
W Queisser, and
U Pepperl, and
U Kempgens, and
U Müller
October 1961,
The American journal of medicine,
W Queisser, and
U Pepperl, and
U Kempgens, and
U Müller
May 1973,
Lancet (London, England),
W Queisser, and
U Pepperl, and
U Kempgens, and
U Müller
November 1973,
The Medical annals of the District of Columbia,
W Queisser, and
U Pepperl, and
U Kempgens, and
U Müller
July 1996,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
W Queisser, and
U Pepperl, and
U Kempgens, and
U Müller
May 2009,
Current opinion in hematology,
W Queisser, and
U Pepperl, and
U Kempgens, and
U Müller
January 2018,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
W Queisser, and
U Pepperl, and
U Kempgens, and
U Müller
January 2013,
TheScientificWorldJournal,
W Queisser, and
U Pepperl, and
U Kempgens, and
U Müller
November 2018,
Blood,
W Queisser, and
U Pepperl, and
U Kempgens, and
U Müller
May 1968,
Annals of internal medicine,
