Biomaterial Database

Neonatal capsaicin administration: effects on behavioral development of the rat. 1994

P Carrillo, and J Manzo, and M Martinez-Gomez, and M Salas, and P Pacheco

Instituto de Neuroetología, Universidad Veracruzana, Xalapa, México.

The effect of a single dose of capsaicin administered neonatally on the development of six motor behavioral patterns (scratching, rearing, grooming, searching, remaining still, and sniffing) was examined in Wistar rats. Treated animals exhibited a significant increment in scratching, rearing, grooming, and searching. Capsaicin also provoked precocious eye opening of one to two days and a reduction in remaining still, sniffing, and body weight. These effects were accompanied by pelage dishevelment and presence of skin ulcers in the region of the head, neck, and shoulders. The distribution of skin ulcers suggests that the fifth cranial nerve and roots innervating C1-C3 spinal cord segments contain a high proportion of capsaicin-sensitive "C" and A delta fibers.

UI	MeSH Term	Description	Entries
D007279	Injections, Subcutaneous	Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.	Subcutaneous Injections,Injection, Subcutaneous,Subcutaneous Injection
D009412	Nerve Fibers	Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM.	Cerebellar Mossy Fibers,Mossy Fibers, Cerebellar,Cerebellar Mossy Fiber,Mossy Fiber, Cerebellar,Nerve Fiber
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D002211	Capsaicin	An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.	8-Methyl-N-Vanillyl-6-Nonenamide,Antiphlogistine Rub A-535 Capsaicin,Axsain,Capsaicine,Capsicum Farmaya,Capsidol,Capsin,Capzasin,Gelcen,Katrum,NGX-4010,Zacin,Zostrix,8 Methyl N Vanillyl 6 Nonenamide,NGX 4010,NGX4010
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000831	Animals, Newborn	Refers to animals in the period of time just after birth.	Animals, Neonatal,Animal, Neonatal,Animal, Newborn,Neonatal Animal,Neonatal Animals,Newborn Animal,Newborn Animals
D001522	Behavior, Animal	The observable response an animal makes to any situation.	Autotomy Animal,Animal Behavior,Animal Behaviors
D012883	Skin Ulcer	An ULCER of the skin and underlying tissues.	Skin Ulcers,Ulcer, Skin,Ulcers, Skin
D017208	Rats, Wistar	A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.	Wistar Rat,Rat, Wistar,Wistar Rats