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Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. 1994
R Wooster, and
S L Neuhausen, and
J Mangion, and
Y Quirk, and
D Ford, and
N Collins, and
K Nguyen, and
S Seal, and
T Tran, and
D Averill
Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey, UK.
A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.
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D Averill
January 1996,
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S L Neuhausen, and
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S Seal, and
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D Averill
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N Collins, and
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T Tran, and
D Averill
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R Wooster, and
S L Neuhausen, and
J Mangion, and
Y Quirk, and
D Ford, and
N Collins, and
K Nguyen, and
S Seal, and
T Tran, and
D Averill
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Nature,
R Wooster, and
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Y Quirk, and
D Ford, and
N Collins, and
K Nguyen, and
S Seal, and
T Tran, and
D Averill
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British journal of cancer,
R Wooster, and
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Y Quirk, and
D Ford, and
N Collins, and
K Nguyen, and
S Seal, and
T Tran, and
D Averill
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Oncogene,
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S L Neuhausen, and
J Mangion, and
Y Quirk, and
D Ford, and
N Collins, and
K Nguyen, and
S Seal, and
T Tran, and
D Averill
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American journal of human genetics,
R Wooster, and
S L Neuhausen, and
J Mangion, and
Y Quirk, and
D Ford, and
N Collins, and
K Nguyen, and
S Seal, and
T Tran, and
D Averill
October 2003,
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,
R Wooster, and
S L Neuhausen, and
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D Ford, and
N Collins, and
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D Averill
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Endocrine-related cancer,
