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Eight calves with osteogenesis imperfecta were born in a Danish Holstein-Friesian herd during a two-year period. In total 92 calves were born (84 normal), and all were sired by a clinically normal Holstein-Friesian bull. The defect was probably due to a de novo dominant mutation present as a gonadal mosaicism in the bull. Affected calves were characterised by multiple fractures, congenital bone deformations, general joint laxity, dentinogenesis imperfecta, and light blue sclerae. The skin seemed normal. Electron microscopical studies revealed slightly decreased average diameter of cutaneous collagen fibrils, while the diameter of collagen fibrils in tendons and ligaments was severely reduced. Abnormalities of collagen type I from skin and compact bone were not detected by biochemical analyses.
J S Agerholm, and
A M Lund, and
B Bloch, and
J Reibel, and
A Basse, and
J Arnbjerg
May 1973,
The Canadian veterinary journal = La revue veterinaire canadienne,
J S Agerholm, and
A M Lund, and
B Bloch, and
J Reibel, and
A Basse, and
J Arnbjerg
February 1995,
The Veterinary record,
J S Agerholm, and
A M Lund, and
B Bloch, and
J Reibel, and
A Basse, and
J Arnbjerg
February 1997,
Acta neuropathologica,
J S Agerholm, and
A M Lund, and
B Bloch, and
J Reibel, and
A Basse, and
J Arnbjerg
January 1990,
Australian veterinary journal,
J S Agerholm, and
A M Lund, and
B Bloch, and
J Reibel, and
A Basse, and
J Arnbjerg
January 1988,
Acta neuropathologica,
J S Agerholm, and
A M Lund, and
B Bloch, and
J Reibel, and
A Basse, and
J Arnbjerg
May 1978,
American journal of veterinary research,
J S Agerholm, and
A M Lund, and
B Bloch, and
J Reibel, and
A Basse, and
J Arnbjerg
December 1993,
Journal of the South African Veterinary Association,
J S Agerholm, and
A M Lund, and
B Bloch, and
J Reibel, and
A Basse, and
J Arnbjerg
January 1983,
Australian veterinary journal,
J S Agerholm, and
A M Lund, and
B Bloch, and
J Reibel, and
A Basse, and
J Arnbjerg
February 1973,
American journal of veterinary research,
J S Agerholm, and
A M Lund, and
B Bloch, and
J Reibel, and
A Basse, and
J Arnbjerg
June 1987,
Zentralblatt fur Veterinarmedizin. Reihe A,
