Inhibitory effect of a soybean-protein--related moiety on iron absorption in humans. 1994

S R Lynch, and S A Dassenko, and J D Cook, and M A Juillerat, and R F Hurrell
University of Kansas Medical Center.

The inhibitory effect of soybean protein isolates on nonheme-iron absorption was studied in 34 human subjects. Iron absorption was measured by using an extrinsic radioiron label in liquid-formula meals containing hydrolyzed corn starch, corn oil, and either egg white or a series of soybean-protein derivatives. The unmodified soybean-protein isolate markedly inhibited iron absorption. Percentage absorption was 19-fold higher when an extensively enzyme-hydrolyzed preparation with very little phytate was used as the protein source. Both the glycinin (11S) and conglycinin (7S) fractions of soybean protein were inhibitory to iron absorption. Dephytinization removed the inhibitory effect of the glycinin but not of the conglycinin fraction. We conclude that there are two major inhibitors of iron absorption in soybean-protein isolates, phytic acid and a protein-related moiety contained in the conglycinin (7S) fraction.

UI MeSH Term Description Entries
D007501 Iron A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. Iron-56,Iron 56
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010206 Papain A proteolytic enzyme obtained from Carica papaya. It is also the name used for a purified mixture of papain and CHYMOPAPAIN that is used as a topical enzymatic debriding agent. EC 3.4.22.2. Tromasin
D010833 Phytic Acid Complexing agent for removal of traces of heavy metal ions. It acts also as a hypocalcemic agent. Inositol Hexaphosphate,Phytin,Calcium Phytate,Inositol Hexakisphosphate,Phytate,Sodium Phytate,Acid, Phytic,Hexakisphosphate, Inositol,Hexaphosphate, Inositol,Phytate, Calcium,Phytate, Sodium
D004044 Dietary Proteins Proteins obtained from foods. They are the main source of the ESSENTIAL AMINO ACIDS. Proteins, Dietary,Dietary Protein,Protein, Dietary
D005260 Female Females
D005916 Globulins A group of proteins that are salt-soluble and form a large fraction of BLOOD PROTEINS. There are three types of globulins, ALPHA-GLOBULINS, BETA-GLOBULINS, and GAMMA-GLOBULINS, which are distinguished from one another by their degree of electrophoretic mobility. Globulin
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006868 Hydrolysis The process of cleaving a chemical compound by the addition of a molecule of water.

Related Publications

S R Lynch, and S A Dassenko, and J D Cook, and M A Juillerat, and R F Hurrell
September 1991, The Journal of nutrition,
S R Lynch, and S A Dassenko, and J D Cook, and M A Juillerat, and R F Hurrell
February 1988, The American journal of clinical nutrition,
S R Lynch, and S A Dassenko, and J D Cook, and M A Juillerat, and R F Hurrell
September 1953, La Riforma medica,
S R Lynch, and S A Dassenko, and J D Cook, and M A Juillerat, and R F Hurrell
May 1992, The Journal of nutrition,
S R Lynch, and S A Dassenko, and J D Cook, and M A Juillerat, and R F Hurrell
January 2003, The American journal of clinical nutrition,
S R Lynch, and S A Dassenko, and J D Cook, and M A Juillerat, and R F Hurrell
August 1981, The American journal of clinical nutrition,
S R Lynch, and S A Dassenko, and J D Cook, and M A Juillerat, and R F Hurrell
January 1995, Journal of toxicology. Clinical toxicology,
S R Lynch, and S A Dassenko, and J D Cook, and M A Juillerat, and R F Hurrell
July 1968, The Tohoku journal of experimental medicine,
S R Lynch, and S A Dassenko, and J D Cook, and M A Juillerat, and R F Hurrell
November 2006, The Journal of nutrition,
S R Lynch, and S A Dassenko, and J D Cook, and M A Juillerat, and R F Hurrell
May 1987, The American journal of clinical nutrition,
Copied contents to your clipboard!