Biomaterial Database

Postnatal development in rat offspring delivered of dams with gestational hyperglycemia. 1994

S Zhong, and J C Dunbar, and K L Jen

Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48202.

OBJECTIVE Our purpose was to test the hypotheses that (1) offspring delivered of dams with gestational hyperglycemia will show metabolic abnormalities and (2) dams with repeated pregnancy but without lactation experience will demonstrate abnormal glucose metabolism long after the delivery of the third litter. METHODS Female rats went through three cycles of gestation-lactation, gestation-nonlactation, or no mating at all. The offspring were reared to 3 months of age, when half of each group were mated. Intravenous glucose tolerance testing was conducted at different times in dams and adult offspring. RESULTS Nonlactation dams showed gestational hyperglycemia, insulin resistance, and hyperlipidemia during the third pregnancy. Impaired intravenous glucose tolerance testing was also apparent 1 week and 3 months after weaning in dams. Adult offspring nursed by nonlactation dams were glucose intolerant and had higher hepatic gluconeogenic enzyme activities and higher lipid levels in the pregnant state. CONCLUSIONS Gestational hyperglycemia produced by repeated gestation without lactation could have a long-lasting effect on adult offspring.

UI	MeSH Term	Description	Entries
D006949	Hyperlipidemias	Conditions with excess LIPIDS in the blood.	Hyperlipemia,Hyperlipidemia,Lipemia,Lipidemia,Hyperlipemias,Lipemias,Lipidemias
D007333	Insulin Resistance	Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.	Insulin Sensitivity,Resistance, Insulin,Sensitivity, Insulin
D007774	Lactation	The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN.	Lactation, Prolonged,Milk Secretion,Lactations, Prolonged,Milk Secretions,Prolonged Lactation,Prolonged Lactations
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D010298	Parity	The number of offspring a female has borne. It is contrasted with GRAVIDITY, which refers to the number of pregnancies, regardless of outcome.	Multiparity,Nulliparity,Primiparity,Parity Progression Ratio,Parity Progression Ratios,Ratio, Parity Progression,Ratios, Parity Progression
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D011248	Pregnancy Complications	Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.	Adverse Birth Outcomes,Complications, Pregnancy,Adverse Birth Outcome,Birth Outcome, Adverse,Complication, Pregnancy,Outcome, Adverse Birth,Pregnancy Complication
D002395	Catecholamines	A general class of ortho-dihydroxyphenylalkylamines derived from TYROSINE.	Catecholamine,Sympathin,Sympathins
D002784	Cholesterol	The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.	Epicholesterol