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We have attempted to determine whether blood concentrations of the alpha chains of TSH arise by direct pituitary secretion of alpha chain or by degradation of the intact hormone after secretion. Highly purified human TSH was administered by infusion to euthyroid volunteers; blood TSH concentrations were raised to 36 muu/ml. After TSH infusion, circulating blood alpha chain concentrations did not change. The same volunteers received an infusion of TRH which stimulated pituitary secretion of TSH, raising blood concentrations to 15 muu/ml in one series of subjects and to 23 muu/ml in a second series. After TRH, blood concentrations of alpha chain increased from undetectable to over 400 pg/ml. We conclude that alpha subunits of TSH are directly secreted by the pituitary gland and are not formed by degradation of intact TSH in the peripheral circulation.
M Edmonds, and
M Molitch, and
J Pierce, and
W D Odell
March 1984,
Israel journal of medical sciences,
M Edmonds, and
M Molitch, and
J Pierce, and
W D Odell
January 1981,
Hormone research,
M Edmonds, and
M Molitch, and
J Pierce, and
W D Odell
June 1990,
Acta endocrinologica,
M Edmonds, and
M Molitch, and
J Pierce, and
W D Odell
February 1969,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M Edmonds, and
M Molitch, and
J Pierce, and
W D Odell
August 1982,
The Journal of clinical endocrinology and metabolism,
M Edmonds, and
M Molitch, and
J Pierce, and
W D Odell
December 1970,
Nihon Naibunpi Gakkai zasshi,
M Edmonds, and
M Molitch, and
J Pierce, and
W D Odell
September 1970,
The Kobe journal of medical sciences,
M Edmonds, and
M Molitch, and
J Pierce, and
W D Odell
September 1986,
Metabolism: clinical and experimental,
M Edmonds, and
M Molitch, and
J Pierce, and
W D Odell
October 1978,
Biochimica et biophysica acta,
M Edmonds, and
M Molitch, and
J Pierce, and
W D Odell
May 1998,
The Journal of clinical endocrinology and metabolism,
