-transparent.png){kind=logo}
NADH dehydrogenase (EC 1.6.99.3) mutations at nucleotide 5460 of mitochondrial DNA (codon 331 of the ND2 subunit gene) have been associated with Alzheimer's disease (BBRC 182, 238-246, 1992; BBRC 189, 1202-1206, 1992). We have sequenced codons 304-347 of this gene in 15 neuropathologically confirmed cases of Alzheimer's disease. In addition, restriction enzyme analysis was performed on the same cases and on 28 control brains. No mutations were detected in the Alzheimer brains but heteroplasmy for a G-->A transition at nucleotide 5460 of mtDNA was found in the frontal cortex of a single control. Thus, our findings do not confirm reports of a significant association between mutations at nucleotide 5460 of mitochondrial DNA and Alzheimer's disease.
S Kösel, and
R Egensperger, and
P Mehraein, and
M B Graeber
July 1987,
Archives of neurology,
S Kösel, and
R Egensperger, and
P Mehraein, and
M B Graeber
January 1992,
Biochemical and biophysical research communications,
S Kösel, and
R Egensperger, and
P Mehraein, and
M B Graeber
January 1983,
Biochimica et biophysica acta,
S Kösel, and
R Egensperger, and
P Mehraein, and
M B Graeber
April 1982,
Biochemical and biophysical research communications,
S Kösel, and
R Egensperger, and
P Mehraein, and
M B Graeber
March 1988,
Bollettino della Societa italiana di biologia sperimentale,
S Kösel, and
R Egensperger, and
P Mehraein, and
M B Graeber
December 2010,
The Malaysian journal of pathology,
S Kösel, and
R Egensperger, and
P Mehraein, and
M B Graeber
June 1989,
Nucleic acids research,
S Kösel, and
R Egensperger, and
P Mehraein, and
M B Graeber
December 1997,
Biochemical and biophysical research communications,
S Kösel, and
R Egensperger, and
P Mehraein, and
M B Graeber
August 2008,
Neuroscience letters,
S Kösel, and
R Egensperger, and
P Mehraein, and
M B Graeber
September 2010,
Neuromolecular medicine,
