-transparent.png){kind=logo}
A series of compounds 1b-f, 2b-f, and 3b-f having an o-chlorobenzenesulfonamidic diuretic moiety variously linked to the nitrogen side chain of the beta-blocking (aryloxy)propanolamine pharmacophore were prepared and tested for their beta 1-adrenoceptor affinity. For all the active compounds, beta-blocking and diuretic activities were investigated in rats; the structure--activity relationships are discussed. Some of the compounds displayed varying levels of both properties and among these, compounds 1c and 2c have been chosen for further development.
Related Publications
V Cecchetti, and
A Fravolini, and
F Schiaffella, and
O Tabarrini, and
G Bruni, and
G Segre
January 1986,
Journal of medicinal chemistry,
V Cecchetti, and
A Fravolini, and
F Schiaffella, and
O Tabarrini, and
G Bruni, and
G Segre
October 1981,
Journal of medicinal chemistry,
V Cecchetti, and
A Fravolini, and
F Schiaffella, and
O Tabarrini, and
G Bruni, and
G Segre
June 1984,
Journal of medicinal chemistry,
V Cecchetti, and
A Fravolini, and
F Schiaffella, and
O Tabarrini, and
G Bruni, and
G Segre
August 1983,
Journal of medicinal chemistry,
V Cecchetti, and
A Fravolini, and
F Schiaffella, and
O Tabarrini, and
G Bruni, and
G Segre
December 1982,
Journal of medicinal chemistry,
V Cecchetti, and
A Fravolini, and
F Schiaffella, and
O Tabarrini, and
G Bruni, and
G Segre
December 1982,
Journal of medicinal chemistry,
V Cecchetti, and
A Fravolini, and
F Schiaffella, and
O Tabarrini, and
G Bruni, and
G Segre
November 1983,
Journal of medicinal chemistry,
V Cecchetti, and
A Fravolini, and
F Schiaffella, and
O Tabarrini, and
G Bruni, and
G Segre
October 1973,
Journal of medicinal chemistry,
V Cecchetti, and
A Fravolini, and
F Schiaffella, and
O Tabarrini, and
G Bruni, and
G Segre
January 1961,
Sinai Hospital journal,
V Cecchetti, and
A Fravolini, and
F Schiaffella, and
O Tabarrini, and
G Bruni, and
G Segre
May 1974,
Journal of medicinal chemistry,
