BIOMAT Database Logo BIOMAT Database Logo

Gastric argyrophil (enterochromaffin-like), gastrin, and somatostatin cells after proximal selective vagotomy in man. 1993

H Koop, and M Frank, and S Kuly, and R Nold, and R Eissele, and G Rager, and J Rüschoff, and M Rothmund, and R Arnold
Department of Medicine, Philipps-University, Marburg, Germany.

The number, size, and volume density of endocrine cells was determined in biopsies obtained endoscopically in patients after proximal selective vagotomy (PSV; N = 31), antrectomy (N = 9), untreated duodenal ulcer (DU) disease (N = 11), and in controls (N = 15). Serum gastrin was significantly elevated after PSV (mean 60 pg/ml) compared to DU patients (29 pg/ml), controls (26 pg/ml), and after antrectomy (11 pg/ml). Volume density of fundic argyrophil (largely enterochromaffin-like) cells after PSV (0.74%) and in DU disease (0.63%) were significantly (P < 0.001) higher when compared with controls (0.37%) but lower after antrectomy (0.24%; P < 0.02). The density of argyrophil cells was not influenced by the interval following PSV or the magnitude of hypergastrinemia. Antral gastrin cells were increased after vagotomy, whereas the antral and fundic somatostatin cell numbers were reduced after PSV. It is concluded that: (1) a major role of the vagal nerve as a trophic factor for enterochromaffin-like cells could not be demonstrated after PSV, and (2) moderate hypergastrinemia after PSV did not induce proliferation of ECL cells.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011706 Pyloric Antrum The region between the sharp indentation at the lower third of the STOMACH (incisura angularis) and the junction of the PYLORUS with the DUODENUM. Pyloric antral glands contain mucus-secreting cells and gastrin-secreting endocrine cells (G CELLS). Antrum, Pyloric,Gastric Antrum,Antrum, Gastric,Antrums, Gastric,Antrums, Pyloric,Gastric Antrums,Pyloric Antrums
D004381 Duodenal Ulcer A PEPTIC ULCER located in the DUODENUM. Curling's Ulcer,Curling Ulcer,Curlings Ulcer,Duodenal Ulcers,Ulcer, Curling,Ulcer, Duodenal,Ulcers, Duodenal
D004759 Enterochromaffin Cells A subtype of enteroendocrine cells found in the gastrointestinal MUCOSA, particularly in the glands of PYLORIC ANTRUM; DUODENUM; and ILEUM. These cells secrete mainly SEROTONIN and some neuropeptides. Their secretory granules stain readily with silver (argentaffin stain). Argentaffin Cells,5-HT-Containing Enterochromaffin Cells,Serotonin-Containing Enterochromaffin Cells,5 HT Containing Enterochromaffin Cells,5-HT-Containing Enterochromaffin Cell,Argentaffin Cell,Cell, Enterochromaffin,Cells, Enterochromaffin,Enterochromaffin Cell,Enterochromaffin Cell, 5-HT-Containing,Enterochromaffin Cell, Serotonin-Containing,Enterochromaffin Cells, 5-HT-Containing,Enterochromaffin Cells, Serotonin-Containing,Serotonin Containing Enterochromaffin Cells,Serotonin-Containing Enterochromaffin Cell
D005260 Female Females
D005743 Gastrectomy Excision of the whole (total gastrectomy) or part (subtotal gastrectomy, partial gastrectomy, gastric resection) of the stomach. (Dorland, 28th ed) Gastrectomies
D005748 Gastric Fundus The superior portion of the body of the stomach above the level of the cardiac notch. Fundus, Gastric
D005753 Gastric Mucosa Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones. Cardiac Glands,Gastric Glands,Pyloric Glands,Cardiac Gland,Gastric Gland,Gastric Mucosas,Gland, Cardiac,Gland, Gastric,Gland, Pyloric,Glands, Cardiac,Glands, Gastric,Glands, Pyloric,Mucosa, Gastric,Mucosas, Gastric,Pyloric Gland
D005755 Gastrins A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters. Gastrin

Related Publications

H Koop, and M Frank, and S Kuly, and R Nold, and R Eissele, and G Rager, and J Rüschoff, and M Rothmund, and R Arnold
Enterochromaffin-like cells and gastric argyrophil carcinoidosis.
January 1991, Acta oncologica (Stockholm, Sweden),
H Koop, and M Frank, and S Kuly, and R Nold, and R Eissele, and G Rager, and J Rüschoff, and M Rothmund, and R Arnold
Gastrin levels after proximal gastric vagotomy.
September 1975, Irish journal of medical science,
H Koop, and M Frank, and S Kuly, and R Nold, and R Eissele, and G Rager, and J Rüschoff, and M Rothmund, and R Arnold
Gastrin levels after proximal gastric vagotomy.
December 1975, Irish journal of medical science,
H Koop, and M Frank, and S Kuly, and R Nold, and R Eissele, and G Rager, and J Rüschoff, and M Rothmund, and R Arnold
[The effects of selective proximal gastric vagotomy on antral mucosal gastrin and somatostatin concentrations].
May 1984, Nihon Geka Gakkai zasshi,
H Koop, and M Frank, and S Kuly, and R Nold, and R Eissele, and G Rager, and J Rüschoff, and M Rothmund, and R Arnold
Identification of somatostatin and gastrin receptors on enterochromaffin-like cells from Mastomys gastric tumors.
July 1992, Endocrinology,
H Koop, and M Frank, and S Kuly, and R Nold, and R Eissele, and G Rager, and J Rüschoff, and M Rothmund, and R Arnold
Somatostatin release induced by gastrin-releasing peptide in man. Effect of proximal gastric vagotomy and cholinergic blockade.
July 1990, Regulatory peptides,
H Koop, and M Frank, and S Kuly, and R Nold, and R Eissele, and G Rager, and J Rüschoff, and M Rothmund, and R Arnold
Effect of selective and proximal gastric vagotomy on serum gastrin.
May 1974, Gastroenterology,
H Koop, and M Frank, and S Kuly, and R Nold, and R Eissele, and G Rager, and J Rüschoff, and M Rothmund, and R Arnold
[Gastric electromyography after selective proximal vagotomy].
January 1981, Sovetskaia meditsina,
H Koop, and M Frank, and S Kuly, and R Nold, and R Eissele, and G Rager, and J Rüschoff, and M Rothmund, and R Arnold
Gastric motility after selective proximal vagotomy.
January 1978, Gastroenterologia Japonica,
H Koop, and M Frank, and S Kuly, and R Nold, and R Eissele, and G Rager, and J Rüschoff, and M Rothmund, and R Arnold
[Gastric ischemia after selective proximal vagotomy].
April 1989, Vestnik khirurgii imeni I. I. Grekova,
Copied contents to your clipboard!