BIOMAT Database Logo BIOMAT Database Logo

Urinary growth hormone in growth-impaired children with chronic inflammatory bowel disease. 1993

C P Braegger, and T Torresani, and S H Murch, and M O Savage, and J A Walker-Smith, and T T MacDonald
Department of Paediatric Gastroenterology, St. Bartholomew's Hospital, London, England.

Growth impairment of undefined aetiology occurs in approximately 30% of children with chronic inflammatory bowel disease. We measured urinary growth hormone concentrations in 36 children with chronic inflammatory bowel disease and 51 normal controls. The median urinary concentration of growth hormone in the stunted children with chronic inflammatory bowel disease was 15.8 ng/g creatinine (range 4.3-32.6), compared with 11.7 ng/g creatinine (range 4.1-35.9) in those with normal growth. The difference was statistically not significant (p = 0.15). Moreover, there was no significant difference between the patients and the control group. One stunted patient had a urinary growth hormone (UGH) concentration below the normal range, whereas four patients with normal height were also below the normal range. Four of these five patients (80%) were on corticosteroid treatment at the time of urinary collection, whereas only 26% of the patients with normal UGH were also on corticosteroid treatment. We conclude that growth retardation in children with chronic inflammatory bowel disease is probably not related to growth hormone deficiency but must involve other mechanisms.

UI MeSH Term Description Entries
D008297 Male Males
D011239 Prednisolone A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states. Di-Adreson-F,Predate,Predonine,Di Adreson F,DiAdresonF
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D003093 Colitis, Ulcerative Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN. Colitis Gravis,Idiopathic Proctocolitis,Inflammatory Bowel Disease, Ulcerative Colitis Type,Ulcerative Colitis
D003404 Creatinine Creatinine Sulfate Salt,Krebiozen,Salt, Creatinine Sulfate,Sulfate Salt, Creatinine
D003424 Crohn Disease A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients. Colitis, Granulomatous,Enteritis, Granulomatous,Enteritis, Regional,Ileitis, Regional,Ileitis, Terminal,Ileocolitis,Crohn's Disease,Crohn's Enteritis,Inflammatory Bowel Disease 1,Regional Enteritis,Crohns Disease,Granulomatous Colitis,Granulomatous Enteritis,Regional Ileitides,Regional Ileitis,Terminal Ileitis
D004797 Enzyme-Linked Immunosorbent Assay An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed. ELISA,Assay, Enzyme-Linked Immunosorbent,Assays, Enzyme-Linked Immunosorbent,Enzyme Linked Immunosorbent Assay,Enzyme-Linked Immunosorbent Assays,Immunosorbent Assay, Enzyme-Linked,Immunosorbent Assays, Enzyme-Linked
D005183 Failure to Thrive A condition of substandard growth or diminished capacity to maintain normal function. Thrive, Failure to
D005260 Female Females
D006130 Growth Disorders Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportions, osseous development, or maturation of features. Included here are both acceleration and retardation of growth. Stunted Growth,Stunting,Disorder, Growth,Growth Disorder,Growth, Stunted,Stuntings

Related Publications

C P Braegger, and T Torresani, and S H Murch, and M O Savage, and J A Walker-Smith, and T T MacDonald
Somatomedin-C levels in growth-impaired children and adolescents with chronic inflammatory bowel disease.
October 1986, Gastroenterology,
C P Braegger, and T Torresani, and S H Murch, and M O Savage, and J A Walker-Smith, and T T MacDonald
Nyctohemeral growth hormone levels in children with growth retardation and inflammatory bowel disease.
March 1973, Gut,
C P Braegger, and T Torresani, and S H Murch, and M O Savage, and J A Walker-Smith, and T T MacDonald
Growth hormone in inflammatory bowel disease.
January 2006, European review for medical and pharmacological sciences,
C P Braegger, and T Torresani, and S H Murch, and M O Savage, and J A Walker-Smith, and T T MacDonald
Improving growth in children with inflammatory bowel disease.
January 2007, Hormone research,
C P Braegger, and T Torresani, and S H Murch, and M O Savage, and J A Walker-Smith, and T T MacDonald
Growth-promoting hormone therapy in inflammatory bowel disease.
December 2010, Journal of pediatric gastroenterology and nutrition,
C P Braegger, and T Torresani, and S H Murch, and M O Savage, and J A Walker-Smith, and T T MacDonald
Growth hormone use in pediatric inflammatory bowel disease.
November 2023, Journal of pediatric endocrinology & metabolism : JPEM,
C P Braegger, and T Torresani, and S H Murch, and M O Savage, and J A Walker-Smith, and T T MacDonald
Pathophysiology and management of abnormal growth in children with chronic inflammatory bowel disease.
January 2013, World review of nutrition and dietetics,
C P Braegger, and T Torresani, and S H Murch, and M O Savage, and J A Walker-Smith, and T T MacDonald
Growth of prepubertal children with inflammatory bowel disease.
March 1998, Journal of pediatric gastroenterology and nutrition,
C P Braegger, and T Torresani, and S H Murch, and M O Savage, and J A Walker-Smith, and T T MacDonald
Growth retardation in chronic inflammatory bowel disease.
October 1986, Gastroenterology,
C P Braegger, and T Torresani, and S H Murch, and M O Savage, and J A Walker-Smith, and T T MacDonald
Severe growth retardation in children with inflammatory bowel disease.
March 1970, Pediatrics,
Copied contents to your clipboard!