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Immunohistochemical studies of pancreatic tissue from patients with cystic fibrosis associated with diabetes mellitus (CFDM) show increased numbers of somatostatin secreting delta cells. To look for a possible functional correlate to this finding basal and arginine stimulated plasma somatostatin and serum C peptide concentrations in eight insulin treated patients with cystic fibrosis and eight normal male controls were measured. Mean basal somatostatin concentrations were not different in the two groups. Mean peak somatostatin concentrations were significantly higher in the group with CFDM: 11.60 pmol/l v 7.14 pmol/l in controls. Mean peak C peptide concentrations were significantly lower in the group with cystic fibrosis: 0.89 nmol/l v 4.27 nmol/l in controls. This observation provides a physiological correlate to the pathological finding of increased somatostatin content in pancreatic tissue from patients with CFDM. Selective preservation of somatostatin secretion in patients with cystic fibrosis may further complicate pancreatic endocrine insufficiencies through paracrine inhibition of insulin and glucagon secretion.
L R Meacham, and
D B Caplan, and
L P McKean, and
C N Buchanan, and
J S Parks, and
F L Culler
October 1993,
Neuroendocrinology,
L R Meacham, and
D B Caplan, and
L P McKean, and
C N Buchanan, and
J S Parks, and
F L Culler
September 2016,
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society,
L R Meacham, and
D B Caplan, and
L P McKean, and
C N Buchanan, and
J S Parks, and
F L Culler
January 2007,
Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia,
L R Meacham, and
D B Caplan, and
L P McKean, and
C N Buchanan, and
J S Parks, and
F L Culler
February 1983,
Biochimica et biophysica acta,
L R Meacham, and
D B Caplan, and
L P McKean, and
C N Buchanan, and
J S Parks, and
F L Culler
July 1976,
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L R Meacham, and
D B Caplan, and
L P McKean, and
C N Buchanan, and
J S Parks, and
F L Culler
September 1995,
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L R Meacham, and
D B Caplan, and
L P McKean, and
C N Buchanan, and
J S Parks, and
F L Culler
April 2010,
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L R Meacham, and
D B Caplan, and
L P McKean, and
C N Buchanan, and
J S Parks, and
F L Culler
January 2005,
Klinika oczna,
L R Meacham, and
D B Caplan, and
L P McKean, and
C N Buchanan, and
J S Parks, and
F L Culler
December 2009,
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society,
L R Meacham, and
D B Caplan, and
L P McKean, and
C N Buchanan, and
J S Parks, and
F L Culler
October 1992,
British medical bulletin,
